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BIA 10-2474 - 98%, high purity , CAS No.1233855-46-3, Inhibitor of Fatty acid amide hydrolase

Moligand™
≥98%

CAS#: 1233855-46-3
Formula: C₁₆H₂₀N₄O₂
Molecular Weight: 300.36
PubChem CID: 46831476

Item Number

B413370

Grouped product items
SKU	Size	Availability	Price
B413370-5mg	5mg	In stock	$58.90
B413370-25mg	25mg	In stock	$265.90
B413370-50mg	50mg	In stock	$370.90
B413370-100mg	100mg	In stock	$573.90

FAAH Inhibitors

View related series

Fatty acid amide hydrolase Inhibitor

Basic Description

Synonyms	1233855-46-3\|BIA 10-2474\|BIA10-2474\|3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide\|BIA-10-2474\|5AP1ZW859M\|CHEMBL4460898\|1H-Imidazole-1-carboxamide, N-cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)-\|N-cyclohexyl-N-methyl-4-(1-oxidopyridi
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Fatty acid amide hydrolase
Product Description	Information BIA 10-2474 BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.

ALogP

1.719

Rotatable Bond

Associated Targets

CES2 Tchem Cocaine esterase 0 Activities

Discover Target: CES2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 1 Activities

Discover Target: FAAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGLL Tchem Monoglyceride lipase 0 Activities

Discover Target: MGLL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide
INCHI	InChI=1S/C16H20N4O2/c1-18(14-7-3-2-4-8-14)16(21)19-11-15(17-12-19)13-6-5-9-20(22)10-13/h5-6,9-12,14H,2-4,7-8H2,1H3
InChi Key	DOWVMJFBDGWVML-UHFFFAOYSA-N
Canonical SMILES	CN(C1CCCCC1)C(=O)N2C=C(N=C2)C3=C[N+](=CC=C3)[O-]
Isomeric SMILES	CN(C1CCCCC1)C(=O)N2C=C(N=C2)C3=C[N+](=CC=C3)[O-]
Alternate CAS	1233855-46-3
PubChem CID	46831476
MeSH Entry Terms	3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide;BIA 10-2474
Molecular Weight	300.36

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2206401	Certificate of Analysis	Jun 29, 2022	B413370
I2206402	Certificate of Analysis	Jun 29, 2022	B413370
I2206403	Certificate of Analysis	Jun 29, 2022	B413370
I2206404	Certificate of Analysis	Jun 29, 2022	B413370

Solubility

Solubility (25°C) In vitro DMSO: 4 mg/mL (13.31 mM); Ethanol: 2 mg/mL (6.65 mM); Water: Insoluble;

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

13.3173525103209

Water(mg / mL) Max Solubility

＜1

References

1. Ulugöl A. (2014) The endocannabinoid system as a potential therapeutic target for pain modulation.. Balkan Med J, 31 (2): (115-20). [PMID:25207181]
2. Lodola A, Castelli R, Mor M, Rivara S. (2015) Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014).. Expert Opin Ther Pat, 25 (11): (1247-66). [PMID:26413912]
3. Kiss LE, Beliaev A, Ferreira HS, Rosa CP, Bonifácio MJ, Loureiro AI, Pires NM, Palma PN, Soares-da-Silva P. (2018) Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase.. ChemMedChem, 13 (20): (2177-2188). [PMID:30113139]

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