Grouped product items

SKU

Size

Availability

Price

Qty

B129831-10mg

10mg

In stock

$76.90

B129831-50mg

50mg

In stock

$253.90

B129831-100mg

100mg

In stock

$406.90

B129831-500mg

500mg

In stock

$1,424.90

B129831-1g

In stock

$2,279.90

Basic Description

Synonyms	AGN 192024 \| (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide \| 17-Phenyltrinor-PGF2α Ethylamide
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Bimatoprost is converted by an amidase enzymatic activity in bovine and human cornea models to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresp
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Prostanoid FP receptor agonist
Note	10mg卖完停产，不再备货
Product Description	Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects

Product Properties

ALogP	2.8

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD1 Tclin D(1A) dopamine receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH2 Tclin Histamine H2 receptor 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGFR Tclin Prostaglandin F2-alpha receptor 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
INCHI	InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
InChi Key	AQOKCDNYWBIDND-FTOWTWDKSA-N
Canonical SMILES	CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Isomeric SMILES	CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O
WGK Germany	3
PubChem CID	5311027
Molecular Weight	415.57

Database links

PubChem CID	5311027
DrugBank Ligand	DB00905
CAS Registry No.	155206-00-1
Wikipedia	Bimatoprost
ChEBI	CHEBI:51230
ChEMBL Ligand	CHEMBL1200963
RCSB PDB Ligand	15M
PEP	bimatoprost
DrugCentral Ligand	371
GPCRdb Ligand	bimatoprost

Certificates

Certificate of Analysis(COA)

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24 results found

Lot Number	Certificate Type	Date	Item
F2228092	Certificate of Analysis	Apr 03, 2024	B129831
F2228094	Certificate of Analysis	Apr 03, 2024	B129831
F2228095	Certificate of Analysis	Apr 03, 2024	B129831
F2228096	Certificate of Analysis	Apr 03, 2024	B129831
E2414209	Certificate of Analysis	Apr 01, 2024	B129831
E2414211	Certificate of Analysis	Apr 01, 2024	B129831
E2414212	Certificate of Analysis	Apr 01, 2024	B129831
B2421158	Certificate of Analysis	Jan 09, 2024	B129831
H2321379	Certificate of Analysis	Aug 10, 2023	B129831
G23211127	Certificate of Analysis	Jun 28, 2023	B129831
G23211199	Certificate of Analysis	Jun 28, 2023	B129831
G23211172	Certificate of Analysis	Jun 28, 2023	B129831
G23211156	Certificate of Analysis	Jun 28, 2023	B129831
G23211153	Certificate of Analysis	Jun 28, 2023	B129831
G23211148	Certificate of Analysis	Jun 28, 2023	B129831
G23211147	Certificate of Analysis	Jun 28, 2023	B129831
G23211144	Certificate of Analysis	Jun 28, 2023	B129831
G23211141	Certificate of Analysis	Jun 28, 2023	B129831
G23211135	Certificate of Analysis	Jun 28, 2023	B129831
G2311156	Certificate of Analysis	Jun 28, 2023	B129831
I2110027	Certificate of Analysis	Jun 15, 2023	B129831
G1527040	Certificate of Analysis	Feb 06, 2023	B129831
F2228093	Certificate of Analysis	May 31, 2022	B129831
G2027130	Certificate of Analysis	May 10, 2022	B129831

Chemical and Physical Properties

Solubility	Soluble in ethanol (~50 mg/ml), methanol, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~300 ug/ml).
Sensitivity	Air Sensitive,Heat Sensitive
Specific Rotation[α]	35° (C=1,MeOH)
Melt Point(°C)	75 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H302:Harmful if swallowed H312:Harmful in contact with skin H360:May damage fertility or the unborn child H340:May cause genetic defects H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
Merck Index	1221

Alternative Products

References

1. Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts 2nd LJ. (2003) Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro.. J Ocul Pharmacol Ther, 19 (1): (45-54). [PMID:12648303]
2. Camras CB, Sharif NA, Wax MB, Stjernschantz J. (2008) Bimatoprost, the prodrug of a prostaglandin analogue.. Br J Ophthalmol, 92 (6): (862-3; author reply 863-4). [PMID:18523093]

Solution Calculators

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Bimatoprost - ≥99%, high purity , Prostanoid FP receptor agonist, CAS No.155206-00-1, Prostanoid FP receptor agonist

Basic Description

Product Properties

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

DRD1 Tclin D(1A) dopamine receptor 0 Activities

DRD2 Tclin D(2) dopamine receptor 0 Activities

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

HRH2 Tclin Histamine H2 receptor 0 Activities

HRH1 Tclin Histamine H1 receptor 0 Activities

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

PTGFR Tclin Prostaglandin F2-alpha receptor 1 Activities

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

DRD3 Tclin D(3) dopamine receptor 0 Activities

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

ABCB11 Tchem Bile salt export pump 0 Activities

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 0 Activities

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

OPRD1 Tclin Delta-type opioid receptor 0 Activities

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

OPRM1 Tclin Mu-type opioid receptor 0 Activities

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

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Dilution Calculator

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