an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations have shown that bimatoprost is conv
Basic Description
Synonyms
17-phenyl trinor PGF2α ethyl amide-d4
Specifications & Purity
A solution in methyl acetate
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Bimatoprost-d4 (17-phenyl trinor PGF2α ethyl amide-d4) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations have shown that bimatoprost is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Bimatoprost-d4is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations have shown that bimatoprost is conv
