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Bimatoprost, free acid - >98%, high purity , CAS No.38344-08-0, Agonist of FP receptor
a metabolically stable analog of PGF2α
Basic Description Synonyms Bimatoprost Acid|38344-08-0|17-phenyl-trinor-PGF2alpha|bimatoprost (free acid form)|17-Phenyl trinor prostaglandin F2alpha|17-phenyl-trinor-Prostaglandin F2alpha|CHEMBL3914661|2683MK55HG|9S,11R,15S-trihydroxy-17-phenyl-18,19,20-trinor-5Z,13E-prostadienoic Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of FP receptor Product Description Bimatoprost, free acid is a metabolically stable analog of PGF|2α|and is a potent agonist for the PGF|2α|(FP receptor). It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF|2α|. Bimatoprost inhibits PGF|2α|binding with a K|i|of 1.1 nM at the rat recombinant FP receptor expressed in CHO cells. The isopropyl ester of bimatoprost is slightly better than PGF|2α|isopropyl ester in reducing the intraocular pressure in the cat eye with no irritation.
Names and Identifiers IUPAC Name (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid INCHI InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,21-,22+/m0/s1 InChi Key YFHHIZGZVLHBQZ-KDACTHKWSA-N Canonical SMILES C1C(C(C(C1O)C=CC(CCC2=CC=CC=C2)O)CC=CCCCC(=O)O)O Isomeric SMILES C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](CCC2=CC=CC=C2)O)C/C=C\CCCC(=O)O)O PubChem CID 5283081 Molecular Weight 388.5
Chemical and Physical Properties Solubility Soluble in PBS (pH 7.2) (~800 g/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml), and DMSO (~100 mg/ml). Refractive Index n20D1.62 (Predicted) Boil Point(°C) 597.38° C at 760 mmHg (Predicted) Melt Point(°C) 244.30° C (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
H360: May damage fertility or the unborn child
H340: May cause genetic defects
H361: Suspected of damaging fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P281: Use personal protective equipment as required.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
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