a biochemical that is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2α by GC- or LC
Basic Description
Synonyms
17-phenyl trinor Prostaglandin F2α-d4
Specifications & Purity
A solution in methyl acetate
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Bimatoprost, free acid-d|4|contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of bimatoprost (free acid) by GC- or LC-mass spectrometry. Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F|2α|(PGF|2α|) and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF|2α|. At the rat recombinant FP receptor expressed in CHO cells bimatoprost (free acid) inhibits PGF2α binding with a K|i|of 1.1 nM. The isopropyl ester of bimatoprost (free acid)-d4 is slightly better than PGF|2α|isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.
