BIO 5192 - ≥98%(HPLC), high purity , CAS No.327613-57-0

Item Number

B286648

Grouped product items
SKU	Size	Availability	Price
B286648-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$209.90
B286648-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$339.90
B286648-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$669.90
B286648-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,069.90

Highly potent and selective inhibitor of integrin α4β1(VLA-4)

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Basic Description

Synonyms	327613-57-0\|BIO 5192\|BIO-5192\|bio5192\|AMD 15057\|AMD-15057\|Butanoic acid, 1-((3,5-dichlorophenyl)sulfonyl)-L-prolyl-N4-(N-methyl-N-((4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-L-leucyl)-2,4-diamino-, (2S)-\|55W0N209OS\|(2(S)-[1-(3,5-Dichlorophe
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Highly selective and potent inhibitor of integrinα4β1(Very Late Antigen-4; VLA-4) (Kd< 10 pM). Selectively bindsα4β1over a range of other integrins (IC50values are 1.8, 138, 1053, > 500 and > 10,000 nM forα4β1,α9β1,α2β1,α4β7andαIIbβ3, respectively). Induc
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-1-(3,5-dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]butanoic acid
INCHI	InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1
InChi Key	MNQBPRHHZPXCKZ-ZDCRTTOTSA-N
Canonical SMILES	CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N(C)C(CC(C)C)C(=O)NCCC(C(=O)O)NC(=O)C3CCCN3S(=O)(=O)C4=CC(=CC(=C4)Cl)Cl
Isomeric SMILES	CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N(C)[C@@H](CC(C)C)C(=O)NCC[C@@H](C(=O)O)NC(=O)[C@@H]3CCCN3S(=O)(=O)C4=CC(=CC(=C4)Cl)Cl
PubChem CID	10350459
Molecular Weight	817.78

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Basic Description