Grouped product items

SKU

Size

Availability

Price

Qty

B102211-25g

25g

In stock

$19.90

B102211-100g

100g

In stock

$68.90

B102211-250g

250g

Available within 4-8 weeks(?)

$85.90

B102211-500g

500g

Available within 4-8 weeks(?)

$153.90

Basic Description

Synonyms	AB01322330-02 \| Decanedioic acid, 1,10-bis(2,2,6,6-tetramethyl-4-piperidinyl) ester \| 2-Methyldihydro-3(2H)-furanone # \| Q15632726 \| Lowilite 77 \| Hillite 77 \| TIN 770 \| Tinuvin 770DF \| Uvinul 4077H \| bis-(2,2,6,6-tetramethylpiperidin-4-yl) sebacate \| bis
Specifications & Purity	≥98%
Shipped In	Normal

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta (0 Activities)

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488188360
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188360
IUPAC Name	bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate
INCHI	InChI=1S/C28H52N2O4/c1-25(2)17-21(18-26(3,4)29-25)33-23(31)15-13-11-9-10-12-14-16-24(32)34-22-19-27(5,6)30-28(7,8)20-22/h21-22,29-30H,9-20H2,1-8H3
InChi Key	XITRBUPOXXBIJN-UHFFFAOYSA-N
Canonical SMILES	CC1(CC(CC(N1)(C)C)OC(=O)CCCCCCCCC(=O)OC2CC(NC(C2)(C)C)(C)C)C
Isomeric SMILES	CC1(CC(CC(N1)(C)C)OC(=O)CCCCCCCCC(=O)OC2CC(NC(C2)(C)C)(C)C)C
WGK Germany	2
RTECS	HD8315000
PubChem CID	164282
UN Number	2811
Molecular Weight	480.72
Reaxy-Rn	3571456

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number	Certificate Type	Date	Item
J1911042	Certificate of Analysis	Jul 07, 2023	B102211
L1825060	Certificate of Analysis	Oct 18, 2022	B102211
F1808087	Certificate of Analysis	Apr 26, 2022	B102211
A2424293	Certificate of Analysis	Mar 07, 2022	B102211
E2231189	Certificate of Analysis	Mar 07, 2022	B102211
E2231191	Certificate of Analysis	Mar 07, 2022	B102211
E2231195	Certificate of Analysis	Mar 07, 2022	B102211
E2231196	Certificate of Analysis	Mar 07, 2022	B102211
E2231199	Certificate of Analysis	Mar 07, 2022	B102211
E2324056	Certificate of Analysis	Mar 07, 2022	B102211
H2231013	Certificate of Analysis	Mar 07, 2022	B102211
I2306005	Certificate of Analysis	Mar 07, 2022	B102211
J2411075	Certificate of Analysis	Mar 07, 2022	B102211

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Chemical and Physical Properties

Solubility	Solubility in Methanol almost transparency
Flash Point(°F)	216 °C
Flash Point(°C)	216°C
Melt Point(°C)	82-85°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects H318:Causes serious eye damage H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H361f:Suspected of damaging fertility
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	2
RTECS	HD8315000
Reaxy-Rn	3571456

References

1. M M Francis,K I Choi,B A Horenstein,R L Papke. (1998-05-20) Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor.. Biophysical journal, 74 ((5)): (2306-2317). [PMID:9591658]
2. A Y Xiao,K Double,T Heinemann,W D Rausch,P Riederer,M Gerlach. (2000-02-01) The industrial chemical Tinuvin 123 does not induce dopaminergic neurotoxicity in C57Bl/6 mice.. Neuroscience letters, 278 ((3)): (165-168). [PMID:10653019]
3. Elisabetta Damiani,Riccardo Castagna,Lucedio Greci. (2002-06-28) The effects of derivatives of the nitroxide tempol on UVA-mediated in vitro lipid and protein oxidation.. Free radical biology & medicine, 33 ((1)): (128-136). [PMID:12086690]
4. Péter Sótonyi,Anikó Kovács,Gábor Volk,Jeno Járay,András Benko. (2004-02-18) Detection of tinuvin 770, a light stabilizer of plastic materials from dialysis membranes, by high-performance liquid chromatographic analysis.. Journal of chromatographic science, 42 ((1)): (49-53). [PMID:14965415]
5. Ngoc H Tran,Mark Scarbecz,John J Gary. (2004-05-22) In vitro evaluation of color change in maxillofacial elastomer through the use of an ultraviolet light absorber and a hindered amine light stabilizer.. The Journal of prosthetic dentistry, 91 ((5)): (483-490). [PMID:15153857]
6. John H Graham,Roger L Papke,Jerry J Buccafusco. (2005-06-25) Functional central nicotinic acetylcholine receptor antagonism by systemic administration of Tinuvin 770 (BTMPS).. Current Alzheimer research, 2 ((2)): (141-147). [PMID:15974911]
7. Martha Gill,Mary Jo Garber,Yousheng Hua,Dennis Jenke. (2010-03-13) Development and validation of an HPLC-MS-MS method for quantitating bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate (Tinuvin 770) and a related substance in aqueous extracts of plastic materials.. Journal of chromatographic science, 48 ((3)): (200-207). [PMID:20223086]
8. Brandon J Hall,Laura S Pearson,Jerry J Buccafusco. (2010-03-17) Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats.. Neuroscience letters, 474 ((2)): (84-87). [PMID:20226229]
9. R L Papke,A G Craig,S F Heinemann. (1994-02-01) Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6-tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics.. The Journal of pharmacology and experimental therapeutics, 268 ((2)): (718-726). [PMID:8113983]
10. H Glossmann,S Hering,A Savchenko,W Berger,K Friedrich,M L Garcia,M A Goetz,J M Liesch,D L Zink,G J Kaczorowski. (1993-10-15) A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.. Proceedings of the National Academy of Sciences of the United States of America, 90 ((20)): (9523-9527). [PMID:8415734]
11. V Jackson-Lewis,G Liberatore. (2000-05-29) Effects of a unilateral stereotaxic injection of Tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat.. Brain research, 866 ((1-2)): (197-210). [PMID:10825495]
12. P Sótonyi,E Keller,J Járay,B Nemes,T Benkõ,A Kovács,A Tolokán,I Rajs. (2001-06-08) A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myocytes.. Forensic science international, 119 ((3)): (322-327). [PMID:11390147]
13. Péter Sótonyi,Béla Merkely,Márta Hubay,Jeno Járay,Endre Zima,Pál Soós,Anikó Kovács,István Szentmáriay. (2003-12-06) Comparative study on cardiotoxic effect of Tinuvin 770: a light stabilizer of medical plastics in rat model.. Toxicological sciences : an official journal of the Society of Toxicology, 77 ((2)): (368-374). [PMID:14657520]
14. David A Tipton,J West Lewis. (2008-09-03) Effects of a hindered amine light stabilizer and a UV light absorber used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts.. The Journal of prosthetic dentistry, 100 ((3)): (220-231). [PMID:18762034]
15. Brandon J Hall,Laura S Pearson,Jerry J Buccafusco. (2009-09-24) Effect of administration of the nicotinic acetylcholine receptor antagonist BTMPS, during nicotine self-administration, on lever responding induced by context long after withdrawal.. Neuropharmacology, 58 ((2)): (429-435). [PMID:19772864]
16. Brandon J Hall,Laura S Pearson,Alvin V Terry,Jerry J Buccafusco. (2011-06-10) The use-dependent, nicotinic antagonist BTMPS reduces the adverse consequences of morphine self-administration in rats in an abstinence model of drug seeking.. Neuropharmacology, 61 ((4)): (798-806). [PMID:21651919]

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Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate - 98%, high purity , CAS No.52829-07-9