| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B409130-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $348.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement. Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. In vivo Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| Canonical SMILES | CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(OC(C)=O)C=C2)C3=CC=CC=N3 |
|---|---|
| Molecular Weight | 361.39 |
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| 1. Chaobin Ren, Abolghasem Jouyban, Hongkun Zhao. (2023) Bisacodyl in aqueous co-solvent solutions of isopropanol/methanol/ethanol: Solubility modeling, preferential solvation and density functional theory study. JOURNAL OF CHEMICAL THERMODYNAMICS, 183 (107054). [PMID:] [10.1016/j.jct.2023.107054] |
| 1. Chaobin Ren, Abolghasem Jouyban, Hongkun Zhao. (2023) Bisacodyl in aqueous co-solvent solutions of isopropanol/methanol/ethanol: Solubility modeling, preferential solvation and density functional theory study. JOURNAL OF CHEMICAL THERMODYNAMICS, 183 (107054). [PMID:] [10.1016/j.jct.2023.107054] |
