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BIX 02188 - ≥98%, high purity , CAS No.1094614-84-2, Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5

  • Moligand™
  • ≥98%
Item Number
B129583
Grouped product items
SKUSizeAvailabilityPrice Qty
B129583-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$162.90
B129583-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$301.90
B129583-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$909.90
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mitogen-activated protein kinase 7 Inhibitor mitogen-activated protein kinase kinase 5 Inhibitor

Basic Description

SynonymsBIX02188|1094614-84-2|334949-59-6|BIX-02188|BIX 02188|(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide|(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide|
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5
Product Description

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Associated Targets

MAPK7 Tchem Mitogen-activated protein kinase 7 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP2K5 Tchem Dual specificity mitogen-activated protein kinase kinase 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indole-6-carboxamide
INCHI InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)
InChi Key WGPXKFOFEXJMBD-UHFFFAOYSA-N
Canonical SMILES CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
Isomeric SMILES CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
PubChem CID 135398492
Molecular Weight 412.48

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Lot NumberCertificate TypeDateItem
E1520126Certificate of AnalysisDec 07, 2022 B129583

Chemical and Physical Properties

SolubilityDMSO 43 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

Related Documents

 SDS

 Specification Sheet

References

1. Tatake RJ, O'Neill MM, Kennedy CA, Wayne AL, Jakes S, Wu D, Kugler Jr SZ, Kashem MA, Kaplita P, Snow RJ.  (2008)  Identification of pharmacological inhibitors of the MEK5/ERK5 pathway..  Biochem Biophys Res Commun,  377  (1): (120-5).  [PMID:18834865]

Solution Calculators

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