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BIX 02189 - ≥98%, high purity , CAS No.1094614-85-3, Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5;Inhibitor of transforming growth factor beta receptor 1

Moligand™
≥98%

CAS#: 1094614-85-3
Formula: C₂₇H₂₈N₄O₂
Molecular Weight: 440.54
PubChem CID: 135659062
PubChem SID: 488202977

Item Number

B129579

Grouped product items
SKU	Size	Availability	Price
B129579-5mg	5mg	In stock	$95.90
B129579-10mg	10mg	In stock	$189.90
B129579-25mg	25mg	In stock	$426.90
B129579-50mg	50mg	In stock	$766.90
B129579-100mg	100mg	In stock	$1,380.90

View related series

mitogen-activated protein kinase 7 Inhibitor mitogen-activated protein kinase kinase 5 Inhibitor transforming growth factor beta receptor 1 Inhibitor

Basic Description

Synonyms	BIX02189\|BIX 02189\|1094614-85-3\|1265916-41-3\|BIX-02189\|(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide\|(E/Z)-BIX02189\|BIX-02189(Random Configuration)\|(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-pheny
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5;Inhibitor of transforming growth factor beta receptor 1
Product Description	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. A MEK5 and ERK5 catalytic activity blocker.

Associated Targets

TGFBR1 Tchem TGF-beta receptor type-1 1 Activities

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK7 Tchem Mitogen-activated protein kinase 7 1 Activities

Discover Target: MAPK7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K5 Tchem Dual specificity mitogen-activated protein kinase kinase 5 1 Activities

Discover Target: MAP2K5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488202977
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202977
IUPAC Name	3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-N,N-dimethyl-1H-indole-6-carboxamide
INCHI	InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,29,32H,17H2,1-4H3
InChi Key	ZGXOBLVQIVXKEB-UHFFFAOYSA-N
Canonical SMILES	CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O
Isomeric SMILES	CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O
Alternate CAS	1265916-41-3
PubChem CID	135659062
MeSH Entry Terms	BIX 02189;BIX-02189;BIX02189
Molecular Weight	440.54

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
D2325354	Certificate of Analysis	Mar 27, 2023	B129579
D2325355	Certificate of Analysis	Mar 27, 2023	B129579
D2325358	Certificate of Analysis	Mar 27, 2023	B129579
D2325359	Certificate of Analysis	Mar 27, 2023	B129579
D2325360	Certificate of Analysis	Mar 27, 2023	B129579
D2325361	Certificate of Analysis	Mar 27, 2023	B129579
D2325363	Certificate of Analysis	Mar 27, 2023	B129579
D2325369	Certificate of Analysis	Mar 27, 2023	B129579
D2325371	Certificate of Analysis	Mar 27, 2023	B129579
D2325476	Certificate of Analysis	Mar 27, 2023	B129579

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