BJE6-106 - 10mM in DMSO, high purity , CAS No.1564249-38-2(DMSO)

  • 10mM in DMSO
Item Number
B654745
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SKUSizeAvailabilityPrice Qty
B654745-1ml
1ml
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$385.90
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Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsBJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC 50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC 50 =50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis . BJE6-106 (B106) possesses tumor-s
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

BJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC 50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC 50 =50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis . BJE6-106 (B106) possesses tumor-specific effect.

In Vitro

BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 24 hours, 48 hours, or 72 hours Result: Inhibited cell survival in melanoma cell lines. Apoptosis AnalysisCell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 6 hours, 12 hours, or 24 hours Result: Induced caspase 3/7 activation. Western Blot AnalysisCell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 2 hours, 5 hours, 10 hours Result: Increased phosphorylation of MKK4, JNK and H2AX.

IC50& Target:PKCδ 0.05 μM (IC 50 ) PKCα 50 μM (IC 50 )

Names and Identifiers

Canonical SMILES CC1(C=CC2=C(O1)C(=CC(=C2)CCN3C4=CC=CC=C4C5=CC=CC=C53)C=O)C
Molecular Weight 381.47

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