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BMS 195614 - ≥97%, high purity , CAS No.253310-42-8
Discover BMS 195614 by Aladdin Scientific in ≥97% for only $227.90. Available - in Ligands at Aladdin Scientific. a neutral RARα (retinoic acid receptor α) inhibitor Tags: .
Basic Description Synonyms BMS614|BMS 195614|253310-42-8|182135-66-6|BMS-195614|4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid|BMS 614|BMS-614|4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid|4-[(5,5-dimethyl-8 Specifications & Purity ≥97% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description BMS 195614 is a selective neutral RARα inhibitor and exhibits no significant effect on NCoR binding. The compound potentially decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).
Product Properties Ki Data Neutral retinoic acid receptor α: Ki= 2.5 nM
Names and Identifiers Pubchem Sid 488189834 IUPAC Name 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid INCHI InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34) InChi Key WGLMBRZXZDAQHP-UHFFFAOYSA-N Canonical SMILES CC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C Isomeric SMILES CC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C Alternate CAS 182135-66-6 PubChem CID 445091 Molecular Weight 448.51
Chemical and Physical Properties Solubility Soluble in DMSO (25 mM). Refractive Index n20D1.69 (Predicted) Boil Point(°C) 607.26° C at 760 mmHg (Predicted) Melt Point(°C) 300.64° C (Predicted)
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