BMS 299897 - ≥98%(HPLC), high purity , CAS No.290315-45-6

Item Number

B287022

Grouped product items
SKU	Size	Availability	Price
B287022-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$30.90
B287022-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$118.90
B287022-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$216.90
B287022-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$358.90
B287022-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$706.90

Potent γ-secretase inhibitor

Basic Description

Synonyms	BMS 299897\|290315-45-6\|BMS-299897\|CHEMBL247471\|QK855F579S\|Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-\|4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic aci
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Orally active, potentγ-secretase inhibitor (IC50= 12 nM). Inhibits Aβ40 and Aβ42 formationin vitro(IC50values are 7.4 and 7.9 nM respectively) and reduces Aβin the brain, plasma and cerebrospinal fluidin vivo. Exhibits no Notch toxicity. Brain penetrant.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP). Application： BMS-299897 has been used as an γ-secretase inhibitor to stop high glucose (HG) mediated amyloid β-peptide (Aβ) secretion.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid
INCHI	InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1
InChi Key	IZAOBRWCUGOKNH-OAHLLOKOSA-N
Canonical SMILES	CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Isomeric SMILES	C[C@H](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
WGK Germany	3
PubChem CID	11249248
Molecular Weight	511.94

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
A2412121	Certificate of Analysis	Dec 04, 2023	B287022
A2412124	Certificate of Analysis	Dec 04, 2023	B287022
A2412126	Certificate of Analysis	Dec 04, 2023	B287022
A2412128	Certificate of Analysis	Dec 04, 2023	B287022
A2412132	Certificate of Analysis	Dec 04, 2023	B287022
A2412134	Certificate of Analysis	Dec 04, 2023	B287022
A2412146	Certificate of Analysis	Dec 04, 2023	B287022
A2412212	Certificate of Analysis	Dec 04, 2023	B287022

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
RIDADR	NONHforallmodesoftransport

Solution Calculators

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Basic Description