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BMS-587101 - 10mM in DMSO, high purity , CAS No.509083-77-6(DMSO)

  • 10mM in DMSO
Item Number
B655243
Grouped product items
SKUSizeAvailabilityPrice Qty
B655243-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$550.90

Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsBMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1) . BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.

In Vitro

BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC 50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production . In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC 50 of 150 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Names and Identifiers

Canonical SMILES O=C(C1=CSC(CN(C[C@H]2C3=CC=C(C#N)C=C3)C[C@]2(N(C)C(N4C5=CC(Cl)=CC(Cl)=C5)=O)C4=O)=C1)O
Molecular Weight 555.43

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C of A & Other Certificates(BSE/TSE, COO)

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