BMS-986176|AAK1-IN-1|1815613-42-3|LX-9211|9G4RLM5X6Z|UNII-9G4RLM5X6Z|LX9211|US10155760, Example 123|(2S)-1-((2',6-Bis(difluoromethyl)(2,4'-bipyridin)-5-yl)oxy)-2,4-dimethyl-2-pentanamine|2-Pentanamine, 1-((2',6-bis(difluoromethyl)(2,4'-bipyridin)-5-yl)oxy
1.Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S et al.. (2022) Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.. J Med Chem, 65 (6):(4534-4564). [PMID:35261239]
2.Hartz RA, Ahuja VT, Nara SJ, Kumar CMV, Brown JM, Bristow LJ, Rajamani R, Muckelbauer JK, Camac D, Kiefer SE et al.. (2021) Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.. J Med Chem, 64 (15):(11090-11128). [PMID:34270254]
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