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SKU | Size | Availability | Price | Qty |
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B648534-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $214.90 | |
B648534-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $450.90 | |
B648534-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $800.90 | |
B648534-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,650.90 |
Synonyms | BMS-986176|AAK1-IN-1|1815613-42-3|LX-9211|9G4RLM5X6Z|UNII-9G4RLM5X6Z|LX9211|US10155760, Example 123|(2S)-1-((2',6-Bis(difluoromethyl)(2,4'-bipyridin)-5-yl)oxy)-2,4-dimethyl-2-pentanamine|2-Pentanamine, 1-((2',6-bis(difluoromethyl)(2,4'-bipyridin)-5-yl)oxy |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC 50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research. |
Storage Temp | Protected from light,Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC 50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research In Vitro Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2 nM (AAK1) |
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IUPAC Name | (2S)-1-[2-(difluoromethyl)-6-[2-(difluoromethyl)pyridin-4-yl]pyridin-3-yl]oxy-2,4-dimethylpentan-2-amine |
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INCHI | InChI=1S/C19H23F4N3O/c1-11(2)9-19(3,24)10-27-15-5-4-13(26-16(15)18(22)23)12-6-7-25-14(8-12)17(20)21/h4-8,11,17-18H,9-10,24H2,1-3H3/t19-/m0/s1 |
InChi Key | RKAHOQATMSONTM-IBGZPJMESA-N |
Canonical SMILES | CC(C)CC(C)(COC1=C(N=C(C=C1)C2=CC(=NC=C2)C(F)F)C(F)F)N |
Isomeric SMILES | CC(C)C[C@@](C)(COC1=C(N=C(C=C1)C2=CC(=NC=C2)C(F)F)C(F)F)N |
Alternate CAS | 1815613-42-3 |
PubChem CID | 118419773 |
Molecular Weight | 385.40 |
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Solubility | DMSO : 220 mg/mL (570.84 mM; Need ultrasonic) |
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