Basic Description

Synonyms	N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent and irreversible BMX inhibitor (IC50= 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residuein vitro. Reduces cell number and induces apoptosis in pros
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of BMX non-receptor tyrosine kinase

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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JAK3 Tclin Tyrosine-protein kinase JAK3 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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BTK Tclin Tyrosine-protein kinase BTK 3 Activities

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BMX Tchem Cytoplasmic tyrosine-protein kinase BMX 2 Activities

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BLK Tchem Tyrosine-protein kinase Blk 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide
INCHI	InChI=1S/C29H24N4O4S/c1-4-27(34)31-26-16-23(12-5-18(26)2)33-28(35)14-9-21-17-30-25-13-8-20(15-24(25)29(21)33)19-6-10-22(11-7-19)32-38(3,36)37/h4-17,32H,1H2,2-3H3,(H,31,34)
InChi Key	SFMJNHNUOVADRW-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
Isomeric SMILES	CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
PubChem CID	71576693
Molecular Weight	524.59

Database links

PubChem CID	71576693
CAS Registry No.	1431525-23-3

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
H2205770	Certificate of Analysis	May 11, 2024	B124925
H2205771	Certificate of Analysis	May 11, 2024	B124925
H2205772	Certificate of Analysis	May 11, 2024	B124925

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 0.52, Max Conc. mM: 1 with gentle warming

References

1. Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C et al.. (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer.. ACS Chem Biol, 8 (7): (1423-8). [PMID:23594111]

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SKU	Size	Availability	Price
B124925-5mg	5mg	In stock	$167.90
B124925-10mg	10mg	In stock	$296.90
B124925-50mg	50mg	In stock	$741.90

BMX-IN-1 - 98%, high purity , CAS No.1431525-23-3, Inhibitor of BMX non-receptor tyrosine kinase