BocNH-PEG4-acid - 97%, high purity , CAS No.876345-13-0

Item Number

B487328

Grouped product items
SKU	Size	Availability	Price	Qty
B487328-100mg	100mg	3	$117.90	+-
B487328-250mg	250mg	6	$216.90	+-
B487328-1g	1g	5	$781.90	+-
B487328-5g	5g	2	$3,515.90	+-

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Basic Description

Specifications & Purity	≥97%
Legal Information	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	Description This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC®molecules) fortargeted protein degradation

Names and Identifiers

Pubchem Sid	488197648
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488197648
IUPAC Name	2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
INCHI	InChI=1S/C15H29NO8/c1-15(2,3)24-14(19)16-4-5-20-6-7-21-8-9-22-10-11-23-12-13(17)18/h4-12H2,1-3H3,(H,16,19)(H,17,18)
InChi Key	SHMYENBXRNPSOG-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)OC(=O)NCCOCCOCCOCCOCC(=O)O
Isomeric SMILES	CC(C)(C)OC(=O)NCCOCCOCCOCCOCC(=O)O
PubChem CID	11660330
Molecular Weight	351.39

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
F2327607	Certificate of Analysis	May 24, 2023	B487328
F2327611	Certificate of Analysis	May 24, 2023	B487328
F2327612	Certificate of Analysis	May 24, 2023	B487328
F2327613	Certificate of Analysis	May 24, 2023	B487328
F2327614	Certificate of Analysis	May 24, 2023	B487328
F2327620	Certificate of Analysis	May 24, 2023	B487328
F2327621	Certificate of Analysis	May 24, 2023	B487328
F2327623	Certificate of Analysis	May 24, 2023	B487328

Chemical and Physical Properties

Refractive Index	n/D 1.4641
Flash Point(°F)	Not applicable
Flash Point(°C)	Not applicable
Molecular Weight	351.390 g/mol
XLogP3	-0.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	16
Exact Mass	351.189 Da
Monoisotopic Mass	351.189 Da
Topological Polar Surface Area	113.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	343.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
RIDADR	NONH for all modes of transport

References

1. Erin A Losey,Matthew D Smith,Meng Meng,Michael D Best. (2009-01-16) Microplate-based analysis of protein-membrane binding interactions via immobilization of whole liposomes containing a biotinylated anchor.. Bioconjugate chemistry, 20 ((2)): (376-383). [PMID:19143516]
2. Hongjun Ren,Fei Xiao,Ke Zhan,Young-Pil Kim,Hexin Xie,Zuyong Xia,Jianghong Rao. (2009-11-20) A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.. Angewandte Chemie (International ed. in English), 48 ((51)): (9658-9662). [PMID:19924746]
3. Jennifer L Brigham,B Gayani K Perera,Dustin J Maly. (2013-01-12) A hexylchloride-based catch-and-release system for chemical proteomic applications.. ACS chemical biology, 8 ((4)): (691-699). [PMID:23305300]
4. Pratistha Ranjitkar,Amanda M Brock,Dustin J Maly. (2010-03-02) Affinity reagents that target a specific inactive form of protein kinases.. Chemistry & biology, 17 ((2)): (195-206). [PMID:20189109]

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Basic Description