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BOP, CAS No.217453-20-8, Antagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit

  • Moligand™
Features and benefits
    Item Number
    rp173588
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp173588-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp173588-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product NameBOP, CAS No.217453-20-8
    Synonymscompound 2;compound 3;N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine
    GradeMoligand™
    Action TypeANTAGONIST
    Mechanism of actionAntagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit

    Associated Targets

    ITGA4 Tclin Integrin alpha-4 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    ITGA9 Tbio Integrin alpha-9 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    ITGB1 Tclin Integrin beta-1 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CAS217453-20-8

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate Namescompound 2;compound 3;N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    Citations of This Product

    1. Kai Feng, Yiling Ruan, Xinmiao Zhang, Xiaojing Wu, Zixuan Liu, Xiaolian Sun.  (2023)  Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis.  ACS Applied Materials & Interfaces,    (24):   [PMID:38031235]

    References

    1. Pepinsky RB, Mumford RA, Chen LL, Leone D, Amo SE, Riper GV, Whitty A, Dolinski B, Lobb RR, Dean DC et al..  (2002)  Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1..  Biochemistry,  41  (22): (7125-41).  [PMID:12033947]
    2. Cao B, Hutt OE, Zhang Z, Li S, Heazlewood SY, Williams B, Smith JA, Haylock DN, Savage GP, Nilsson SK.  (2014)  Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells..  Org Biomol Chem,  12  (6): (965-78).  [PMID:24363056]
    3. Kai Feng, Yiling Ruan, Xinmiao Zhang, Xiaojing Wu, Zixuan Liu, Xiaolian Sun.  (2023)  Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis.  ACS Applied Materials & Interfaces,    (24):   [PMID:38031235]

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