Grouped product items

SKU

Size

Availability

Price

Qty

B741818-20000US

20000US Unit

Available within 8-12 weeks(?)

$855.90

B741818-100000US

100000 US Unit

Available within 8-12 weeks(?)

$1,380.90

Basic Description

Product Name

Bovine Thrombin

Grade

High Purity

Product Description

Test	Specification
Thrombin Activity (by coagulation)	> 200,000 US units/g powder
Protein (by Biuret)	not specified
Thrombin Specific Activity	> 2200 US units/mg powder
Moisture	0 - 5%
pH (1% solution)	6.5 - 7.5
Salt Environment	Glycine, Sodium Chloride
Recommended diluent for reconstitution	0.9% NaCl

This product is forin vitro (diagnostic) use only. Not for human or animal consumption.

The high purity bovine thrombin (> 2200 U/mg protein) is used by many diagnostic companies worldwide to defibrinate plasma, producing serum matrixes to be used as controls and standards or in polyclonal antibody production. Using bovine thrombin in polyclonal antibody production to defibrinate plasma may increase antibody yields by 15-20% over off-the-clot methods of defibrination.

Our high purity thrombin is also used to cleave His Tags and GST Tags with a high degree of specificity. We express our units in US Units (aka, NIH Units) measured by coagulation. There are approximately 5 Thrombin cleavage units for every one US Unit.

Specifications & Purity

High Purity, > 2200 U/Mg Protein

Product Properties

Nacres	NA.54

Product Specifications

Concentration	> 2200 U/Mg Protein
CAS	9002-04-4
Enzyme Commission Number	3.4.21.5 (BRENDA, IUBMB)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

Citations of This Product

1. Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339]
2. Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu. (2023) A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 297 (122740). [PMID:37080047]
3. Xinxin Ren, Qingqing Zhang, Lingxia Qin, Kaiyue Hu, Zhiyong Guo, Sui Wang, Yufang Hu. (2023) Checkerboard arranged G4 nanostructure-supported electrochemical platform and its application to unique bio-enzymes examination. BIOELECTROCHEMISTRY, 149 (108282). [PMID:36242949]
4. Xinxin Ren, Kaiyue Hu, Lingxia Qin, Di Wu, Zhiyong Guo, Sui Wang, Yufang Hu. (2022) Development of ZnO nanoflowers-assisted DNAzyme-based electrochemical platform for invertase and glucose oxidase-dominated biosensing. ANALYTICA CHIMICA ACTA, 1232 (340438). [PMID:36257731]
5. Songzhi Xie, Chuanfei Mo, Wenxiong Cao, Shuang Xie, Shang Li, Zhanlin Zhang, Xiaohong Li. (2022) Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents. Acta Biomaterialia, 142 (49). [PMID:35158079]
6. Fuad Abduro Bushira, Shimeles Addisu Kitte, Yong Wang, Haijuan Li, Ping Wang, Yongdong Jin. (2021) Plasmon-Boosted Cu-Doped TiO2 Oxygen Vacancy-Rich Luminol Electrochemiluminescence for Highly Sensitive Detection of Alkaline Phosphatase. ANALYTICAL CHEMISTRY, 93 (45): (15183–15191). [PMID:34743510]
7. Qing Zhu, Ping Ye, Fang Guo, Yimen Zhu, Wenbin Nan, Zhaohua Chang. (2021) A heparin-functionalized covered stent prepared by plasma technology. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:34672223]
8. Ting Cheng,Xiang Li,Peng Huang,Han Wang,Meixia Wang,Wenming Yang. (2019-01-12) Colorimetric and electrochemical (dual) thrombin assay based on the use of a platinum nanoparticle modified metal-organic framework (type Fe-MIL-88) acting as a peroxidase mimic.. Mikrochimica acta, 186 ((2)): (94-94). [PMID:30631938]

References

1. Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339]
2. Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu. (2023) A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 297 (122740). [PMID:37080047]
3. Xinxin Ren, Qingqing Zhang, Lingxia Qin, Kaiyue Hu, Zhiyong Guo, Sui Wang, Yufang Hu. (2023) Checkerboard arranged G4 nanostructure-supported electrochemical platform and its application to unique bio-enzymes examination. BIOELECTROCHEMISTRY, 149 (108282). [PMID:36242949]
4. Xinxin Ren, Kaiyue Hu, Lingxia Qin, Di Wu, Zhiyong Guo, Sui Wang, Yufang Hu. (2022) Development of ZnO nanoflowers-assisted DNAzyme-based electrochemical platform for invertase and glucose oxidase-dominated biosensing. ANALYTICA CHIMICA ACTA, 1232 (340438). [PMID:36257731]
5. Songzhi Xie, Chuanfei Mo, Wenxiong Cao, Shuang Xie, Shang Li, Zhanlin Zhang, Xiaohong Li. (2022) Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents. Acta Biomaterialia, 142 (49). [PMID:35158079]
6. Fuad Abduro Bushira, Shimeles Addisu Kitte, Yong Wang, Haijuan Li, Ping Wang, Yongdong Jin. (2021) Plasmon-Boosted Cu-Doped TiO2 Oxygen Vacancy-Rich Luminol Electrochemiluminescence for Highly Sensitive Detection of Alkaline Phosphatase. ANALYTICAL CHEMISTRY, 93 (45): (15183–15191). [PMID:34743510]
7. Qing Zhu, Ping Ye, Fang Guo, Yimen Zhu, Wenbin Nan, Zhaohua Chang. (2021) A heparin-functionalized covered stent prepared by plasma technology. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:34672223]
8. Ting Cheng,Xiang Li,Peng Huang,Han Wang,Meixia Wang,Wenming Yang. (2019-01-12) Colorimetric and electrochemical (dual) thrombin assay based on the use of a platinum nanoparticle modified metal-organic framework (type Fe-MIL-88) acting as a peroxidase mimic.. Mikrochimica acta, 186 ((2)): (94-94). [PMID:30631938]

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