Grouped product items

SKU

Size

Availability

Price

Qty

B413658-2mg

2mg

In stock

$132.90

B413658-5mg

5mg

In stock

$276.90

B413658-10mg

10mg

In stock

$513.90

B413658-25mg

25mg

In stock

$979.90

B413658-50mg

50mg

In stock

$1,583.90

Basic Description

Synonyms	Zatolmilast\|BPN14770\|1606974-33-7\|Zatolmilast [USAN]\|BPN-14770\|2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetic acid\|G786V328X6\|CHEMBL4541964\|UNII-G786V328X6\|WHO 11495\|Benzeneacetic acid, 4-((2-(3-chlorophenyl)-6-(trifluorome
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	BPN14770 is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of phosphodiesterase 4D
Product Description	Information BPN14770 is a selective allosteric inhibitor ofphosphodiesterase 4D (PDE4D)with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Targets PDE4D3 (Cell-free assay); PDE4D7 (Cell-free assay) 7.4 nM; 7.8 nM

Product Properties

ALogP	6.3
Rotatable Bond	6

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE11A Tchem Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 0 Activities

Discover Target: PDE11A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 0 Activities

Discover Target: PDE8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE7A Tclin High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 0 Activities

Discover Target: PDE7A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE10A Tclin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0 Activities

Discover Target: PDE10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1 Activities

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE9A Tchem High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 0 Activities

Discover Target: PDE9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4C Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4C 0 Activities

Discover Target: PDE4C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 0 Activities

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B 0 Activities

Discover Target: PDE3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

Discover Target: PDE4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0 Activities

Discover Target: PDE4B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE1C Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0 Activities

Discover Target: PDE1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE1A Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0 Activities

Discover Target: PDE1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE6C Tclin Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0 Activities

Discover Target: PDE6C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE2A Tclin cGMP-dependent 3',5'-cyclic phosphodiesterase 0 Activities

Discover Target: PDE2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE7B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 7B 0 Activities

Discover Target: PDE7B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE1B Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0 Activities

Discover Target: PDE1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic acid
INCHI	InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)
InChi Key	LTSUMTMGJHPGFX-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F
Isomeric SMILES	C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F
Alternate CAS	1606974-33-7
PubChem CID	90111638
MeSH Entry Terms	2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetic acid;BPN14770
Molecular Weight	405.8

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot Number	Certificate Type	Date	Item
K2218225	Certificate of Analysis	Aug 29, 2022	B413658
K2218270	Certificate of Analysis	Aug 29, 2022	B413658
K2218376	Certificate of Analysis	Aug 29, 2022	B413658
K2218378	Certificate of Analysis	Aug 29, 2022	B413658
K2218385	Certificate of Analysis	Aug 29, 2022	B413658

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 81 mg/mL (199.6 mM); Ethanol: 81 mg/mL (199.6 mM); Water: ˂1 mg/mL
DMSO(mg / mL) Max Solubility	81
DMSO(mM) Max Solubility	199.605717102021
Water(mg / mL) Max Solubility	˂1

Alternative Products

References

1. Briet C, Pereda A, Le Stunff C, Motte E, de Dios Garcia-Diaz J, de Nanclares GP, Dumaz N, Silve C. (2017) Mutations causing acrodysostosis-2 facilitate activation of phosphodiesterase 4D3.. Hum Mol Genet, 26 (20): (3883-3894). [PMID:29016851]
2. Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox 3rd D, O'Donnell JM, Zhang C, Xu Y, Zhang HT et al.. (2019) Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.. J Med Chem, 62 (10): (4884-4901). [PMID:31013090]
3. Gurney ME. (2019) Genetic Association of Phosphodiesterases With Human Cognitive Performance.. Front Mol Neurosci, 12 (3): (22). [PMID:30800055]

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BPN14770 - 98%, high purity , CAS No.1606974-33-7, Allosteric modulator of phosphodiesterase 4D

Basic Description

Product Properties

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

PDE11A Tchem Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 0 Activities

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 0 Activities

PDE7A Tclin High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 0 Activities

PDE10A Tclin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0 Activities

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1 Activities

PDE9A Tchem High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 0 Activities

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

PDE4C Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4C 0 Activities

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase 0 Activities

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B 0 Activities

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

PDE4B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0 Activities

PDE1C Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0 Activities

PDE1A Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0 Activities

PDE6C Tclin Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0 Activities

PDE2A Tclin cGMP-dependent 3',5'-cyclic phosphodiesterase 0 Activities

PDE7B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 7B 0 Activities

PDE1B Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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