Brassinolide is a plant hormone; a natural steroid containing a seven-membered B-ring lactone, that promotes both cell elongation and cell devision and is used as a plant growth regulator. Description: IC50 Value: N/A Brassinolide is a plant sterol first isolated from pollen of rape (Brassica napus L.), Brassinolide could promote stem elongation and cell division. in vitro: Caspase-3 activity was obviously increased after brassinolide treatment. Western blot studies indicated that treatment with brassinolide triggered a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2 [1]. After treatment of brassinolide under the concentration of 0.001 - 10.0 microg x mL(-1), the resistance of CCRF-VCR was reversed partly with the reversing folds respectively as 4.4 - 11.6 [2]. After brassinolide treatment, the expression of p53 in CCRF-VCR cells restored to the level of sensitive cells. in vivo: After oral administration of Brassinolide for consecutive 7 days(once every day),the levels of blood glucose were evaluated on the day 0 and the day 7 [3]. Clinical trial: N/A
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