BRD0705 - 98%, high purity , CAS No.2056261-41-5

Item Number

B414436

• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

GSK3α (Cell-free assay); GSK3β (Cell-free assay); GSK3α (Cell-free assay) 66 nM; 515 nM(Kd); 4.8 μM(Kd)

In vitro

BRD0705 inhibits kinase function and does not stabilize β-catenin, mitigating potential neoplastic concerns. BRD0705 induces myeloid differentiation and impairs colony formation in AML cells while no effect is observed on normal hematopoietic cells.

BRD0705 impairs leukemia initiation and prolongs survival in AML mouse models.

Cell Research(from reference)

Cell lines：HEK 293T, HL-60, U937, TF-1, NB-4, MV4–11, MOLM-13, Mononuclear cells 

Concentrations：20 μM 

Incubation Time：24 hours