Brevilin A - 98%, high purity , CAS No.16503-32-5

Item Number

B413675

Grouped product items
SKU	Size	Availability	Price
B413675-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$72.90
B413675-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$216.90
B413675-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$373.90
B413675-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$639.90
B413675-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,023.90

JAK2 Selective Inhibitors

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Basic Description

Synonyms	[(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate \| AC-34175 \| EKT624Z4TZ \| Ambros-2-en-12-oic acid, 6alpha,8beta-dihydroxy-4-oxo-, 12,8-lactone, 2-methylcrotonate, (Z)- \|
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product description Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Targets：STAT3； JAK

Names and Identifiers

IUPAC Name	[(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate
INCHI	InChI=1S/C20H26O5/c1-6-10(2)18(22)25-17-16-12(4)19(23)24-14(16)9-11(3)13-7-8-15(21)20(13,17)5/h6-8,11-14,16-17H,9H2,1-5H3/b10-6-/t11-,12+,13+,14-,16-,17+,20+/m1/s1
InChi Key	KUPPZVXLWANEJJ-UXPPPGSFSA-N
Canonical SMILES	CC=C(C)C(=O)OC1C2C(C(=O)OC2CC(C3C1(C(=O)C=C3)C)C)C
Isomeric SMILES	C/C=C(/C)\C(=O)O[C@H]1[C@@H]2[C@@H](C(=O)O[C@@H]2C[C@H]([C@H]3[C@]1(C(=O)C=C3)C)C)C
PubChem CID	12302076
Molecular Weight	346.42

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
B2423743	Certificate of Analysis	Jan 15, 2024	B413675
B2423745	Certificate of Analysis	Jan 15, 2024	B413675
B2423756	Certificate of Analysis	Jan 15, 2024	B413675
B2423757	Certificate of Analysis	Jan 15, 2024	B413675
B2423758	Certificate of Analysis	Jan 15, 2024	B413675
B2423759	Certificate of Analysis	Jan 15, 2024	B413675
B2423760	Certificate of Analysis	Jan 15, 2024	B413675
B2423761	Certificate of Analysis	Jan 15, 2024	B413675
B2423762	Certificate of Analysis	Jan 15, 2024	B413675
B2423764	Certificate of Analysis	Jan 15, 2024	B413675

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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Basic Description