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brexpiprazole - 97%, high purity , Serotonin 2a (5-HT2a) receptor antagonist, CAS No.913611-97-9, Serotonin 2a (5-HT2a) receptor antagonist
Basic Description Synonyms BREXPIPRAZOLE|913611-97-9|OPC-34712|Rexulti|7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one|OPC 34712|Rxulti|UNII-2J3YBM1K8C|2J3YBM1K8C|Brexpiprazole-d8|7-(4-(4-(1-Benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one|Brexpip Specifications & Purity Moligand™, ≥97% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST, PARTIAL AGONIST Mechanism of action Serotonin 2a (5-HT2a) receptor antagonist
Names and Identifiers IUPAC Name 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one INCHI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29) InChi Key ZKIAIYBUSXZPLP-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4 Isomeric SMILES C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4 PubChem CID 11978813 Molecular Weight 433.57
Chemical and Physical Properties Solubility ≥21.68 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H351: Suspected of causing cancer
H302: Harmful if swallowed
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
References 1. Maeda K, Sugino H, Akazawa H, Amada N, Shimada J, Futamura T, Yamashita H, Ito N, McQuade RD, Mørk A et al. . (2014) Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.. J Pharmacol Exp Ther, 350 (3): (589-604). [PMID:24947465 ] 2. Citrome L. (2015) Brexpiprazole for schizophrenia and as adjunct for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antipsychotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?. Int J Clin Pract, 69 (9): (978-97). [PMID:26250067 ]
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G2419038