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brimapitide, CAS No.rp173597, Inhibitor of mitogen-activated protein kinase 10

  • Moligand™
Features and benefits
    Item Number
    rp173597
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp173597-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp173597-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product Namebrimapitide, CAS No.rp173597
    SynonymsAM-111;D-JNKI-1;XG-102
    GradeMoligand™
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of mitogen-activated protein kinase 10

    Associated Targets

    MAPK10 Tchem Mitogen-activated protein kinase 10 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp173597

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesAM-111;D-JNKI-1;XG-102
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Barkdull GC, Hondarrague Y, Meyer T, Harris JP, Keithley EM.  (2007)  AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis..  Laryngoscope,  117  (12): (2174-82).  [PMID:18322422]
    2. Omotehara Y, Hakuba N, Hato N, Okada M, Gyo K.  (2011)  Protection against ischemic cochlear damage by intratympanic administration of AM-111..  Otol Neurotol,  32  (9): (1422-7).  [PMID:22089955]
    3. Reinecke K, Eminel S, Dierck F, Roessner W, Kersting S, Chromik AM, Gavrilova O, Laukevicience A, Leuschner I, Waetzig V et al..  (2012)  The JNK inhibitor XG-102 protects against TNBS-induced colitis..  PLoS ONE,  (3): (e30985).  [PMID:22427801]
    4. Suckfuell M, Lisowska G, Domka W, Kabacinska A, Morawski K, Bodlaj R, Klimak P, Kostrica R, Meyer T.  (2014)  Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: a double-blind, randomized, placebo-controlled phase II study..  Otol Neurotol,  35  (8): (1317-26).  [PMID:24979398]

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