| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B655298-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $198.90 |
Phenols Polyphenols
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis In Vitro Broussonin E (20 μM, 3 h) inhibits the LPS ( Lipopolysaccharides , HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK. Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3. Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS. Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells. IC50& Target:ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10 |
| Canonical SMILES | COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O |
|---|---|
| Molecular Weight | 288.34 |
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