a highly potent, selective, and irreversible inhibitor of BTK
Basic Description
Specifications & Purity
≥98%
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Bruton's tyrosine kinase inhibitor III is a cell-permeable pyrrolopyridinyl-acryloyl compound which acts as a highly potent, selective, and irreversible inhibitor of Btk (IC|50|= 720 pM) as well as affecting Lyn, Lck, and Itk activity only at much higher concentrations (IC|50|= 14 nM, 97 nM, and 1.0 μM, respectively). It inhibits BTK-dependent PLC-phosphorylation and Ca|2+|flux in human B cell line, Ramos|in vitro|(IC|50|= 14 nM and 40 nM, respectively) and is of excellent efficacy in a murine rheumatoid archritis model. Bruton′s Tyrosine Kinase Inhibitor IIIis a highly potent, selective, and irreversible inhibitor of BTK
