Bryostatin 2 , CAS No.87745-28-6

Item Number

B339273

Grouped product items
SKU	Size	Availability	Price	Qty
B339273-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$256.90
B339273-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$712.90

a macrocyclic lactone and antagonist of phorbol ester action

Basic Description

Synonyms	(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadieno
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Bryostatin 2 is a macrocyclic lactone with anti-tumor properties and activator of PKC (protein kinase C) which inhibit the growth of A549 cells. Bryostatin 2 has been documented to compete with phorbol ester binding to PKC at a K\|i\|= 3.4 nM and antagonizes phorbol esteraction. The compound has been observed to induce variable arachidonic acid release. Bryostatin 2 has demonstrated to synergistically, with recombinant B cell stimulatory factor-1, cause differentiation in resting lymph node T cells. Bryostatin 2 also exhibits growth inhibitory activity against several human cancer cell lines.

Names and Identifiers

IUPAC Name	[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate
INCHI	InChI=1S/C45H66O16/c1-9-10-11-12-13-14-37(49)59-41-29(21-39(51)56-8)20-32-24-35(27(2)46)58-40(52)23-30(47)22-33-25-36(48)43(5,6)44(53,60-33)26-34-18-28(19-38(50)55-7)17-31(57-34)15-16-42(3,4)45(41,54)61-32/h11-16,19,21,27,30-36,41,46-48,53-54H,9-10,17-18,20,22-26H2,1-8H3/b12-11+,14-13+,16-15+,28-19+,29-21+/t27-,30-,31+,32+,33-,34+,35-,36+,41+,44+,45-/m1/s1
InChi Key	LIPGUSBNMQRYNL-IZBIBDMISA-N
Canonical SMILES	CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)O)O)C(C)O
Isomeric SMILES	CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)O)O)[C@@H](C)O
PubChem CID	6438131
Molecular Weight	863

Solubility

Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).

Refractive Index

n20D1.57 (Predicted)

Boil Point(°C)

~957.2° C at 760 mmHg (Predicted)

Solution Calculators

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Basic Description