Skip to the beginning of the images gallery

BSJ-03-123 - ≥98%(HPLC), high purity , CAS No.2361493-16-3, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Moligand™
≥98%(HPLC)

CAS#: 2361493-16-3
Formula: C₄₇H₅₆N₁₀O₁₁
Molecular Weight: 937.02
PubChem CID: 137628658
PubChem SID: 488203024

Item Number

B286699

Grouped product items
SKU	Size	Availability	Price
B286699-5mg	5mg	In stock	$246.90
B286699-10mg	10mg	In stock	$345.90
B286699-25mg	25mg	In stock	$544.90
B286699-50mg	50mg	In stock	$741.90
B286699-100mg	100mg	In stock	$1,187.90

Selective Cdk6 degrader

View related series

cyclin dependent kinase 4 Inhibitor cyclin dependent kinase 6 Inhibitor

Basic Description

Synonyms	N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective Cdk6 degrader (DC50in sub 10 μM range). Displays no degradation of closely related Cdk4.Negative controlBSJ-Bump also available.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK4 Tclin Cyclin-dependent kinase 4 0 Activities

Discover Target: CDK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK6 Tclin Cyclin-dependent kinase 6 0 Activities

Discover Target: CDK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488203024
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488203024
IUPAC Name	N-[2-[2-[2-[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
INCHI	InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)
InChi Key	LUHCYAOYQIFNRN-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C
Isomeric SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C
PubChem CID	137628658
Molecular Weight	937.02

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
E23291335	Certificate of Analysis	Apr 14, 2023	B286699
E23291346	Certificate of Analysis	Apr 14, 2023	B286699
E23291359	Certificate of Analysis	Apr 14, 2023	B286699
E23291365	Certificate of Analysis	Apr 14, 2023	B286699
E23291366	Certificate of Analysis	Apr 14, 2023	B286699
E2329891	Certificate of Analysis	Apr 14, 2023	B286699
E2329897	Certificate of Analysis	Apr 14, 2023	B286699
E2329902	Certificate of Analysis	Apr 14, 2023	B286699
E2329915	Certificate of Analysis	Apr 14, 2023	B286699
E2329962	Certificate of Analysis	Apr 14, 2023	B286699

Solubility

Solvent:DMSO, Max Conc. mg/mL: 93.7, Max Conc. mM: 100

Sensitivity

light sensitive

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.