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BSJ-03-204 - 96%, high purity , CAS No.2349356-09-6, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Moligand™
≥96%

CAS#: 2349356-09-6
Formula: C₄₃H₄₈N₁₀O₈
Molecular Weight: 832.92
PubChem CID: 139593561

Item Number

B287296

Grouped product items
SKU	Size	Availability	Price
B287296-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
B287296-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$639.90
B287296-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,279.90

Selective Cdk4/6 degrader

View related series

cyclin dependent kinase 4 Inhibitor cyclin dependent kinase 6 Inhibitor

Basic Description

Synonyms	N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Specifications & Purity	96%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6
Product Description	BSJ-03-204 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity。

Associated Targets

CDK4 Tclin Cyclin-dependent kinase 4 0 Activities

Discover Target: CDK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK6 Tclin Cyclin-dependent kinase 6 0 Activities

Discover Target: CDK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
INCHI	InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49)
InChi Key	KDMOCOWXLQOXEB-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C
PubChem CID	139593561
Molecular Weight	832.92

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6 results found

Lot Number	Certificate Type	Date	Item
G2408321	Certificate of Analysis	Mar 04, 2024	B287296
G2408322	Certificate of Analysis	Mar 04, 2024	B287296
G2408323	Certificate of Analysis	Mar 04, 2024	B287296
G2408324	Certificate of Analysis	Mar 04, 2024	B287296
G2408325	Certificate of Analysis	Mar 04, 2024	B287296
G2408326	Certificate of Analysis	Mar 04, 2024	B287296

Solubility

Solvent:DMSO, Max Conc. mg/mL: 16.66, Max Conc. mM: 20

Sensitivity

Light sensitive

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