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CMGC:Containing CDK, MAPK, GSK3, CLK families
BSJ-04-132 , CAS No.B608234, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

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BSJ-04-132 , CAS No.B608234, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Moligand™

PubChem CID: 139593562

Item Number

B608234

Grouped product items
SKU	Size	Availability	Price	Qty
B608234-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$304.90
B608234-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,060.90

View related series

cyclin dependent kinase 4 Inhibitor cyclin dependent kinase 6 Inhibitor

Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Associated Targets

CDK4 Tclin Cyclin-dependent kinase 4 0 Activities

Discover Target: CDK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK6 Tclin Cyclin-dependent kinase 6 0 Activities

Discover Target: CDK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
INCHI	InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)
InChi Key	GWLSXEHHNOBFOI-UHFFFAOYSA-N
Canonical SMILES	O=C(COc1cccc2c1C(=O)N(C2=O)C1CCC(=O)NC1=O)NCCCCN1CCN(CC1)c1ccc(nc1)Nc1ncc2c(n1)n(C1CCCC1)c(c2)C(=O)N(C)C
PubChem CID	139593562

Database links

PubChem CID	139593562

Certificates

Certificate of Analysis(COA)

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References

1. Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS. (2019) Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.. Angew Chem Int Ed Engl, 58 (19): (6321-6326). [PMID:30802347]

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