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Butaprost, free acid - A solution in methyl acetate, high purity , CAS No.433219-55-7, Agonist of DP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of IP receptor;Agonist of TP receptor

  • Moligand™
  • A solution in methyl acetate
Item Number
B347295
Grouped product items
SKUSizeAvailabilityPrice Qty
B347295-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$261.90
B347295-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$137.90
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a selective EP2 agonist

View related series
DP1 receptor Agonist EP2 receptor Agonist EP3 receptor Agonist EP4 receptor Agonist IP receptor Agonist TP receptor Agonist

Basic Description

Specifications & PurityMoligand™, A solution in methyl acetate
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of DP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of IP receptor;Agonist of TP receptor
Product Description

Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400 nM, whereas butaprost (free acid) and CAY10399 (the 2-series congener of butaprost free acid) exhibit significantly lower Ki values of 73 and 92 nM, respectively. Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.

Product Properties

pKapKₐ: 4.77 (Predicted)
Ki DataEP2 receptor-transfected CHO cells: Ki= 73 nM; EP2: Ki= 110 nM (human); EP4: Ki= >10 μM (human)

Associated Targets

PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 7-[(1R,2R,3R)-3-hydroxy-2-[(E,4S)-4-hydroxy-4-(1-propylcyclobutyl)but-1-enyl]-5-oxocyclopentyl]heptanoic acid
INCHI InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1
InChi Key PAYNQYXOKJDXAV-ZHIWTBQHSA-N
Canonical SMILES CCCC1(CCC1)C(CC=CC2C(CC(=O)C2CCCCCCC(=O)O)O)O
Isomeric SMILES CCCC1(CCC1)[C@H](C/C=C/[C@H]2[C@@H](CC(=O)[C@@H]2CCCCCCC(=O)O)O)O
PubChem CID 25886893
UN Number 1231
Packing Group II
Molecular Weight 394.6

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in water (100 ug/ml at 25° C), ethanol (~50 mg/ml), DMSO (25 mg/ml), DMF (25 mg/ml), and PBS (pH 7.2) (100 ug/ml).
Refractive Indexn20D1.56 (Predicted)
Boil Point(°C)57° C

Safety and Hazards(GHS)

Class 3

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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