BW A868C - A solution in ethanol,>98%, high purity , CAS No.118675-50-6, Antagonist of DP 1 receptor

Item Number

B337961

Grouped product items
SKU	Size	Availability	Price	Qty
B337961-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$133.90
B337961-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,064.90

a hydantoin compound structurally related to the DP agonist BW245C

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Basic Description

Synonyms	BW A868C\|118675-50-6\|BWA868C\|BW-A868C\|3-Benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)hydantoin\|4-Imidazolidineheptanoicacid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-\|7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)am
Specifications & Purity	A solution in ethanol,>98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of DP 1 receptor
Product Description	BW A868C is a hydantoin compound structurally related to the DP agonist BW245C. BW A868C antagonizes prosaglandin D2 and BW245C-induced activation of human platelet adenylate cyclase. Has been shown to antagonize accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. Shows virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Ki is approximately 1.7 nM.

Names and Identifiers

IUPAC Name	7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl]heptanoic acid
INCHI	InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)
InChi Key	YZJVWSKJHGEIBL-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)C(CNN2C(C(=O)N(C2=O)CC3=CC=CC=C3)CCCCCCC(=O)O)O
Isomeric SMILES	C1CCC(CC1)C(CNN2C(C(=O)N(C2=O)CC3=CC=CC=C3)CCCCCCC(=O)O)O
WGK Germany	3
Alternate CAS	118675-50-6
PubChem CID	122021
MeSH Entry Terms	3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)hydantoin;BW 868C;BW A 868C;BW A868C;BW-A-868C;BW-A868C;BWA868C
Molecular Weight	459.58

PubChem CID

CAS Registry No.

GPCRdb Ligand

Solubility

Soluble in water (0.25 mg/ml at 25° C), DMSO (~20 mg/ml), DMF (~20 mg/ml), PBS (pH 7.2) (~0.25 mg/ml), and ethanol.

Refractive Index

n20D1.59 (Predicted)

Boil Point(°C)

78° C (Predicted)

WGK Germany

RIDADR

NONHforallmodesoftransport

Solution Calculators

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Basic Description