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BW-B 70C - ≥98%(HPLC), high purity , CAS No.134470-38-5, Inhibitor of 5-LOX

Moligand™
≥98%(HPLC)

CAS#: 134470-38-5
Formula: C₁₇H₁₇FN₂O₃
Molecular Weight: 316.33
PubChem CID: 5353454

Item Number

B288192

Grouped product items
SKU	Size	Availability	Price
B288192-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$86.90
B288192-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
B288192-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
B288192-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$538.90
B288192-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$969.90

5-Lipoxygenase inhibitor

View related series

5-LOX Inhibitor

Basic Description

Synonyms	BW B70C\|134470-38-5\|BWB70C\|BW-B70C\|BW-B 70C\|(E)-N-(3-(3-(4-Fluorophenoxy)phenyl)-1-(R,S)-methylprop-2-enyl)-N-hydroxyurea\|1-[(E)-4-[3-(4-fluorophenoxy)phenyl]but-3-en-2-yl]-1-hydroxyurea\|CHEMBL86676\|CHEBI:75307\|N-(3-(3-(4-Fluorophenoxy)phenyl)-1-methyl-2-
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailabilityin vivo.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of 5-LOX
Product Description	BW B70C is a potent and selective acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

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FTL Tbio Ferritin light chain 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 1 Activities

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LMNA Tbio Prelamin-A/C 0 Activities

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ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NPSR1 Tchem Neuropeptide S receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[(E)-4-[3-(4-fluorophenoxy)phenyl]but-3-en-2-yl]-1-hydroxyurea
INCHI	InChI=1S/C17H17FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-12,22H,1H3,(H2,19,21)/b6-5+
InChi Key	UAIYNMRLUHHRMF-AATRIKPKSA-N
Canonical SMILES	CC(C=CC1=CC(=CC=C1)OC2=CC=C(C=C2)F)N(C(=O)N)O
Isomeric SMILES	CC(/C=C/C1=CC(=CC=C1)OC2=CC=C(C=C2)F)N(C(=O)N)O
WGK Germany	3
RTECS	YT3976666
PubChem CID	5353454
Molecular Weight	316.33

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

Solubility

Solvent:ethanol, Max Conc. mg/mL: None, Max Conc. mM: 3; Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 3

Melt Point(°C)

>134°C (dec.)

WGK Germany

RTECS

YT3976666

RIDADR

NONHforallmodesoftransport

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