Compound E, gamma;-secretase inhibitor - ≥99%, high purity , CAS No.209986-17-4

Item Number

C275008

Grouped product items
SKU	Size	Availability	Price	Qty
C275008-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$157.90
C275008-250μg	250μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$47.90

Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor

Basic Description

Synonyms	Compound E\|209986-17-4\|gamma-Secretase Inhibitor XXI\|C27H24F2N4O3\|(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide\|(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-
Specifications & Purity	≥99%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Dry ice
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
INCHI	InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
InChi Key	JNGZXGGOCLZBFB-IVCQMTBJSA-N
Canonical SMILES	CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
Isomeric SMILES	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
PubChem CID	11306390
Molecular Weight	490.5

References

1. Naylor RW et al.. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion.. Elife, 7 [PMID:30394875]
2. Liu X et al.. (2018) BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway.. Exp Ther Med, 16 (6): (4623-4631). [PMID:30542413]
3. Kang Y et al.. (2018) Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.. Cell Rep, 25 (9): (2563-2576.e9). [PMID:30485820]
4. Zhang YF et al.. (2022) MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1.. Front Cell Neurosci, 16 (866020). [PMID:35685988]
5. Alhashem Z et al.. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration.. Elife, 11 [PMID:35438077]
6. Slaninova V et al.. (2016) Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle.. Open Biol, 6 (2): (150155). [PMID:26887408]

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Basic Description