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CaCCinh-A01 - ≥99%(HPLC), high purity , CAS No.407587-33-1, Channel blocker of CaCC

  • Moligand™
  • ≥99%(HPLC)
Item Number
C288015
Grouped product items
SKUSizeAvailabilityPrice Qty
C288015-5mg
5mg
In stock
$64.90
C288015-10mg
10mg
In stock
$102.90
C288015-25mg
25mg
In stock
$226.90
C288015-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$375.90
C288015-100mg
100mg
In stock
$632.90
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Calcium-activated chloride channel (CaCC) inhibitor

View related series
CaCC Channel blocker

Basic Description

Synonyms6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid；(R)-6-(tert-butyl)-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsCalcium-activated chloride channel (CaCC) inhibitor (IC50~ 10μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50= 2.1μM, in TMEM16A-expressing FRT cells).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of CaCC

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ANO2 Tchem Anoctamin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ANO1 Tclin Anoctamin-1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-tert-butyl-2-(furan-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
INCHI InChI=1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)
InChi Key ACLUEOBQFRYTQS-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3
Isomeric SMILES CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3
PubChem CID 2898877
Molecular Weight 347.43

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
B2308146Certificate of AnalysisOct 27, 2022 C288015
B2308147Certificate of AnalysisOct 27, 2022 C288015
B2308148Certificate of AnalysisOct 27, 2022 C288015
B2308149Certificate of AnalysisOct 27, 2022 C288015
B2308151Certificate of AnalysisOct 27, 2022 C288015

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 34.74, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.47, Max Conc. mM: 10 with gentle warming

Related Documents

 SDS

 Specification Sheet

References

1. De La Fuente R, Namkung W, Mills A, Verkman AS.  (2008)  Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel..  Mol Pharmacol,  73  (3): (758-68).  [PMID:18083779]

Solution Calculators

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