Cafestol - ≥98%, high purity , CAS No.469-83-0

Item Number

C274912

• Synonyms: cafestol|469-83-0|cafesterol|CCRIS 1518|AC465T6Q6W|CHEBI:3291|(3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol|UNII-AC465T6Q6W|SR-05000002204|(-)-cafesto
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Coffee-specific diterpene. Induces peripheral antinociception and glutathione S-transferases. Chemoprotective activity.
• Source: Coffea sp.
• Storage Temp: Protected from light,Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.