caffeic acid|3,4-Dihydroxycinnamic acid|331-39-5|trans-caffeic acid|501-16-6|3,4-Dihydroxybenzeneacrylic acid|3-(3,4-dihydroxyphenyl)acrylic acid|(E)-3-(3,4-dihydroxyphenyl)acrylic acid|(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid|Caffeicacid|Cinnamic ac
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
Specific NF-κB inhibitor (IC 50 = 8.8 μM). Antioxidant, immunomodulatory and anti-inflammatory effects in vitro and in vivo . Additionally inhibits HDAC (IC 50 = 0.85 mM). Blood-brain barrier permeable.
Storage Temp
Store at 2-8°C,Argon charged
Shipped In
Wet ice
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Caffeic Acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid caffeic acid inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase. An inhibitor of 5-LO and 12-LO.
E2428199
