Basic Description

Synonyms	AE-562/40879347 \| Calcium hydrogenphosphate dihydrate, p.a., 98.0-105.0% \| CALCIUM PHOSPHATE DIHYDRATE [WHO-DD] \| DIBASIC CALCIUM PHOSPHATE HYDRATE [JAN] \| brushite \| CALCIUM PHOSPHATE, DIBASIC, DIHYDRATE [II] \| DIBASIC CALCIUM PHOSPHATE DIHYDRATE [USP MO
Specifications & Purity	PharmPure™, USP, BP, Ph.Eur., ≥98%
Shipped In	Normal
Grade	BP, Ph.Eur., PharmPure™, USP

Names and Identifiers

IUPAC Name	calcium;hydrogen phosphate;dihydrate
INCHI	InChI=1S/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-2
InChi Key	XAAHAAMILDNBPS-UHFFFAOYSA-L
Canonical SMILES	O.O.OP(=O)([O-])[O-].[Ca+2]
Isomeric SMILES	O.O.OP(=O)([O-])[O-].[Ca+2]
PubChem CID	104805
Molecular Weight	172.09

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
A2119031	Certificate of Analysis	Nov 04, 2024	C108378

Chemical and Physical Properties

Sensitivity	Moisture sensitive.

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Lei Chen, Shitong Zhang, Bo Zhang, Qian Liang, Dong Luo, Xiaojiao Yu, Binghua Yao, Kang Zhao, Zhao Yang, Yufei Tang, Zixiang Wu. (2023) Study on the poly(methyl methacrylate-acrylic acid)/calcium phosphate cement composite bound by chelation with enhanced water absorption and biomechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 147 (6): (106149). [PMID:37782989] [10.1016/j.jmbbm.2023.106149]
2. Fupo He, Jin Rao, Wenhao Fu, Jielin Zhou, Yuxuan Zhang, Tengyun Chen, Wenhao Huang, Yao Wang, Teliang Lu, Haishan Shi. (2023) 3D printing and physicochemical and biological characterizations of gallium-containing magnesium/calcium phosphate ceramic scaffolds. CERAMICS INTERNATIONAL, [PMID:] [10.1016/j.ceramint.2023.08.127]
3. Tao Zhou-Shan, Li Tian-Lin, Wei Shan. (2023) Co-modified 3D printed β-tricalcium phosphate with magnesium and selenium promotes bone defect regeneration in ovariectomized rat. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 34 (1): (1-14). [PMID:36622473] [10.1007/s10856-022-06708-w]
4. Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu. (2022) Enhanced mechanical properties and anti-washout of calcium phosphate cement/montmorillonite composite bone-cement for bone-repair applications. CERAMICS INTERNATIONAL, 48 (35185). [PMID:] [10.1016/j.ceramint.2022.08.117]
5. Hongwei Chen, Changchang Lv, Lin Guo, Ming Ma, Xiangfeng Li, Zhengyi Lan, Jun Huo, Hao Dong, Xiangdong Zhu, Qiang Zhu, Yuming Gu, Ziteng Liu, Jianjun Liu, Hangrong Chen, Xuefeng Guo, Jing Ma. (2022) Surface Stability and Morphology of Calcium Phosphate Tuned by pH Values and Lactic Acid Additives: Theoretical and Experimental Study. ACS Applied Materials & Interfaces, 14 (4): (4836–4851). [PMID:35043625] [10.1021/acsami.1c18727]
6. ZhiDong Lin, XuLin Hu, LiLun Zhong, DeQiang Peng, JunLin Lu, Jian He, Xiaofei Shen, ChengDong Xiong, Tao Xu, Wei Niu. (2021) Doping polyvinyl alcohol can improve the injectability of biological ceramics in 3D printing and influence the adhesion of cells to the scaffolds after sintering. CERAMICS INTERNATIONAL, 47 (25363). [PMID:] [10.1016/j.ceramint.2021.05.258]
7. Teliang Lu, Shenglei Feng, Fupo He, Jiandong Ye. (2019) Enhanced osteogenesis of honeycomb β-tricalcium phosphate scaffold by construction of interconnected pore structure: An in vivo study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 108 (3): (645-653). [PMID:31747100] [10.1002/jbm.a.36844]
8. Gu Yifan, Zhang Jing, Zhang Xinzhi, Liang Guiping, Xu Tao, Niu Wei. (2019) Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro. Tissue Engineering and Regenerative Medicine, 16 (4): (415-429). [PMID:31413945] [10.1007/s13770-019-00192-0]
9. Guowen Qian, Xingmei Li, Fupo He, Jiandong Ye. (2019) Improving the anti-washout property of calcium phosphate cement by introducing konjac glucomannan/κ-carrageenan blend. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:30661443] [10.1177/0885328218824762]
10. Qian Guowen, Li Xingmei, He Fupo, Ye Jiandong. (2018) Improvement of anti-washout property of calcium phosphate cement by addition of konjac glucomannan and guar gum. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 29 (12): (1-11). [PMID:30511166] [10.1007/s10856-018-6193-7]
11. Shenglei Feng, Fupo He, Jiandong Ye. (2017) Fabrication and characterization of honeycomb β-tricalcium phosphate scaffolds through an extrusion technique. CERAMICS INTERNATIONAL, 43 (6778). [PMID:] [10.1016/j.ceramint.2017.02.094]
12. Ming Wang, Liping Wang, Chao Shi, Tian Sun, Yi Zeng, Yingchun Zhu. (2016) The crystal structure and chemical state of aluminum-doped hydroxyapatite by experimental and first principles calculation studies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18 (31): (21789-21796). [PMID:27436334] [10.1039/C6CP03230C]
13. Peng Wang, Pengzheng Liu, Haitao Peng, Xiaoman Luo, Huipin Yuan, Juncai Zhang, Yonggang Yan. (2016) Biocompatibility evaluation of dicalcium phosphate/calcium sulfate/poly (amino acid) composite for orthopedic tissue engineering in vitro and in vivo. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 27 (11): (1170-1186). [PMID:27126299] [10.1080/09205063.2016.1184123]
14. Xiu Yan Ren, Zhe Yu, Baijun Liu, Xue Jiao Liu, Ya Jun Wang, Qiang Su, Guang Hui Gao. (2016) Highly tough and puncture resistant hydrogels driven by macromolecular microspheres. RSC Advances, 6 (11): (8956-8963). [PMID:] [10.1039/C5RA24778K]

References

1. P Tschoppe,A M Kielbassa,H Meyer-Lueckel. (2009-07-15) Evaluation of the remineralizing capacities of modified saliva substitutes in vitro.. Archives of oral biology, 54 ((9)): (810-816). [PMID:19595293]
2. A C Magalhães,B M Moron,L P Comar,A Wiegand,W Buchalla,M A R Buzalaf. (2009-12-18) Comparison of cross-sectional hardness and transverse microradiography of artificial carious enamel lesions induced by different demineralising solutions and gels.. Caries research, 43 ((6)): (474-483). [PMID:20016178]
3. Yuehua Guo,Shuxin Qu,Xiong Lu,Haodong Xie,Hongping Zhang,Jie Weng. (2009-12-19) The theoretical and experimental study on dicalcium phosphate dehydrate loading with protocatechuic aldehyde.. Journal of molecular modeling, 16 ((7)): (1187-1194). [PMID:20020311]
4. F Michaut,V Busignies,C Fouquereau,B Huet de Barochez,B Leclerc,P Tchoreloff. (2009-12-30) Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products.. Journal of pharmaceutical sciences, 99 ((6)): (2874-2885). [PMID:20039388]
5. Van Viet Thai,Byong-Taek Lee. (2010-03-25) Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using hydroxy-propyl-methyl-cellulose and citric acid.. Journal of materials science. Materials in medicine, 21 ((6)): (1867-1874). [PMID:20333539]
6. H Meyer-Lueckel,H Cölfen,A Verch,P Tschoppe. (2010-04-02) Effects of carboxymethyl cellulose-based saliva substitutes with varying degrees of saturation with respect to calcium phosphates on artificial enamel lesions.. Caries research, 44 ((2)): (127-134). [PMID:20357442]
7. Ramin Rohanizadeh,Kimberly Chung. (2010-07-29) Hydroxyapatite as a carrier for bone morphogenetic protein.. The Journal of oral implantology, 37 ((6)): (659-672). [PMID:20662667]
8. Verena Schnitzler,Franck Fayon,Christelle Despas,Ibrahim Khairoun,Charlotte Mellier,Thierry Rouillon,Dominique Massiot,Alain Walcarius,Pascal Janvier,Olivier Gauthier,Gilles Montavon,Jean-Michel Bouler,Bruno Bujoli. (2010-09-22) Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: critical influence of the drug introduction mode on the in vitro cement properties.. Acta biomaterialia, 7 ((2)): (759-770). [PMID:20854940]
9. Sarsvatkumar Patel,Arvind Kumar Bansal. (2010-11-03) Prediction of mechanical properties of compacted binary mixtures containing high-dose poorly compressible drug.. International journal of pharmaceutics, 403 ((1-2)): (109-114). [PMID:21034802]
10. Simo-Pekka Simonaho,T Aleksi Takala,Marko Kuosmanen,Jarkko Ketolainen. (2011-03-02) Ultrasound transmission measurements for tensile strength evaluation of tablets.. International journal of pharmaceutics, 409 ((1-2)): (104-110). [PMID:21356298]
11. Silvia Panzavolta,Barbara Bracci,Katia Rubini,Adriana Bigi. (2011-07-06) Optimization of a biomimetic bone cement: role of DCPD.. Journal of inorganic biochemistry, 105 ((8)): (1060-1065). [PMID:21726768]
12. Chikage Kato,Masaya Suzuki,Koichi Shinkai,Yoshiroh Katoh. (2011-09-29) Histopathological and immunohistochemical study on the effects of a direct pulp capping experimentally developed adhesive resin system containing reparative dentin-promoting agents.. Dental materials journal, 30 ((5)): (583-597). [PMID:21946478]
13. Dong Chen,Nicky Bertollo,Abe Lau,Naoya Taki,Tomofumi Nishino,Hajime Mishima,Haruo Kawamura,William R Walsh. (2011-11-08) Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model.. Journal of orthopaedic surgery and research, 6 (56-56). [PMID:22053991]
14. Andrew M Cassidy,Catherine E Gardner,Tony Auffret,Barry Aldous,William Jones. (2012-01-17) Decoupling the effects of surface chemistry and humidity on solid-state hydrolysis of aspirin in the presence of dicalcium phosphate dihydrate.. Journal of pharmaceutical sciences, 101 ((4)): (1496-1507). [PMID:22246632]
15. Daniel L Alge,W Scott Goebel,Tien-Min Gabriel Chu. (2012-02-11) In vitro degradation and cytocompatibility of dicalcium phosphate dihydrate cements prepared using the monocalcium phosphate monohydrate/hydroxyapatite system reveals rapid conversion to HA as a key mechanism.. Journal of biomedical materials research. Part B, Applied biomaterials, 100 ((3)): (595-602). [PMID:22323239]
16. Dindo Mijares,Anupama Kulkarni,Kanthi Lewis,Fang Yao,Qing Xi,Samar Tannous,Renata Dias,Racquel Z LeGeros. (2012-03-20) Oral bone loss induced by mineral deficiency in a rat model: effect of a synthetic bone mineral (SBM) preparation.. Archives of oral biology, 57 ((9)): (1264-1273). [PMID:22424637]
17. Daniel L Alge,Jeffrey Bennett,Trevor Treasure,Sherry Voytik-Harbin,W Scott Goebel,Tien-Min Gabriel Chu. (2012-04-11) Poly(propylene fumarate) reinforced dicalcium phosphate dihydrate cement composites for bone tissue engineering.. Journal of biomedical materials research. Part A, 100 ((7)): (1792-1802). [PMID:22489012]
18. Guiling Zhang,Rong Huang,Zhicheng Li,Xianyan Yang,Xiaoyi Chen,Wei Xia,Xiaoliang Sun,Guojing Yang,Changyou Gao,Zhongru Gou. (2012-06-13) Understanding the influence of alendronate on the morphology and phase transformation of apatitic precursor nanocrystals.. Journal of inorganic biochemistry, 113 (1-8). [PMID:22687488]
19. Shinji Morimoto,Takahisa Anada,Yoshitomo Honda,Osamu Suzuki. (2012-06-29) Comparative study on in vitro biocompatibility of synthetic octacalcium phosphate and calcium phosphate ceramics used clinically.. Biomedical materials (Bristol, England), 7 ((4)): (045020-045020). [PMID:22740587]
20. Shuji Noguchi,Ryusuke Kajihara,Yasunori Iwao,Yukari Fujinami,Yoshio Suzuki,Yasuko Terada,Kentaro Uesugi,Keiko Miura,Shigeru Itai. (2013-02-05) Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation.. International journal of pharmaceutics, 445 ((1-2)): (93-98). [PMID:23376507]
21. Daniel L Alge,W Scott Goebel,Tien-Min Gabriel Chu. (2013-02-23) Effects of DCPD cement chemistry on degradation properties and cytocompatibility: comparison of MCPM/β-TCP and MCPM/HA formulations.. Biomedical materials (Bristol, England), 8 ((2)): (025010-025010). [PMID:23428798]
22. J Tonannavar,Gouri Deshpande,Jayashree Yenagi,Siddanagouda B Patil,Nikhil A Patil,B G Mulimani. (2015-10-27) Identification of mineral compositions in some renal calculi by FT Raman and IR spectral analysis.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 154 (20-26). [PMID:26495905]
23. J M Lausier,C W Chiang,H A Zompa,C T Rhodes. (1977-11-01) Aging of tablets made with dibasic calcium phosphate dihydrate as matrix.. Journal of pharmaceutical sciences, 66 ((11)): (1636-1637). [PMID:915749]
24. Sarsvatkumar Patel,Aditya Mohan Kaushal,Arvind Kumar Bansal. (2010-01-20) Mechanistic investigation on pressure dependency of Heckel parameter.. International journal of pharmaceutics, 389 ((1-2)): (66-73). [PMID:20083173]
25. S Tadier,N Le Bolay,C Rey,C Combes. (2010-12-15) Co-grinding significance for calcium carbonate-calcium phosphate mixed cement. Part I: effect of particle size and mixing on solid phase reactivity.. Acta biomaterialia, 7 ((4)): (1817-1826). [PMID:21147278]
26. Peter Tschoppe,Hendrik Meyer-Lueckel. (2011-02-05) Mineral distribution of artificial dentinal caries lesions after treatment with fluoride agents in combination with saliva substitutes.. Archives of oral biology, 56 ((8)): (775-784). [PMID:21292240]
27. Faleh Tamimi,Damien Le Nihouannen,Hazem Eimar,Zeeshan Sheikh,Svetlana Komarova,Jake Barralet. (2012-04-24) The effect of autoclaving on the physical and biological properties of dicalcium phosphate dihydrate bioceramics: brushite vs. monetite.. Acta biomaterialia, 8 ((8)): (3161-3169). [PMID:22522010]
28. Mazeyar Parvinzadeh Gashti,Manuela Stir,Jürg Hulliger. (2013-06-14) Synthesis of bone-like micro-porous calcium phosphate/iota-carrageenan composites by gel diffusion.. Colloids and surfaces. B, Biointerfaces, 110 (426-433). [PMID:23759383]
29. Daniel M Moreira,Justin I Friedlander,Christopher Hartman,Sammy E Elsamra,Arthur D Smith,Zeph Okeke. (2013-06-25) Differences in 24-hour urine composition between apatite and brushite stone formers.. Urology, 82 ((4)): (768-772). [PMID:23791217]
30. Lei Chen, Shitong Zhang, Bo Zhang, Qian Liang, Dong Luo, Xiaojiao Yu, Binghua Yao, Kang Zhao, Zhao Yang, Yufei Tang, Zixiang Wu. (2023) Study on the poly(methyl methacrylate-acrylic acid)/calcium phosphate cement composite bound by chelation with enhanced water absorption and biomechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 147 (6): (106149). [PMID:37782989] [10.1016/j.jmbbm.2023.106149]
31. Fupo He, Jin Rao, Wenhao Fu, Jielin Zhou, Yuxuan Zhang, Tengyun Chen, Wenhao Huang, Yao Wang, Teliang Lu, Haishan Shi. (2023) 3D printing and physicochemical and biological characterizations of gallium-containing magnesium/calcium phosphate ceramic scaffolds. CERAMICS INTERNATIONAL, [PMID:] [10.1016/j.ceramint.2023.08.127]
32. Tao Zhou-Shan, Li Tian-Lin, Wei Shan. (2023) Co-modified 3D printed β-tricalcium phosphate with magnesium and selenium promotes bone defect regeneration in ovariectomized rat. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 34 (1): (1-14). [PMID:36622473] [10.1007/s10856-022-06708-w]
33. Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu. (2022) Enhanced mechanical properties and anti-washout of calcium phosphate cement/montmorillonite composite bone-cement for bone-repair applications. CERAMICS INTERNATIONAL, 48 (35185). [PMID:] [10.1016/j.ceramint.2022.08.117]
34. Hongwei Chen, Changchang Lv, Lin Guo, Ming Ma, Xiangfeng Li, Zhengyi Lan, Jun Huo, Hao Dong, Xiangdong Zhu, Qiang Zhu, Yuming Gu, Ziteng Liu, Jianjun Liu, Hangrong Chen, Xuefeng Guo, Jing Ma. (2022) Surface Stability and Morphology of Calcium Phosphate Tuned by pH Values and Lactic Acid Additives: Theoretical and Experimental Study. ACS Applied Materials & Interfaces, 14 (4): (4836–4851). [PMID:35043625] [10.1021/acsami.1c18727]
35. ZhiDong Lin, XuLin Hu, LiLun Zhong, DeQiang Peng, JunLin Lu, Jian He, Xiaofei Shen, ChengDong Xiong, Tao Xu, Wei Niu. (2021) Doping polyvinyl alcohol can improve the injectability of biological ceramics in 3D printing and influence the adhesion of cells to the scaffolds after sintering. CERAMICS INTERNATIONAL, 47 (25363). [PMID:] [10.1016/j.ceramint.2021.05.258]
36. Teliang Lu, Shenglei Feng, Fupo He, Jiandong Ye. (2019) Enhanced osteogenesis of honeycomb β-tricalcium phosphate scaffold by construction of interconnected pore structure: An in vivo study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 108 (3): (645-653). [PMID:31747100] [10.1002/jbm.a.36844]
37. Gu Yifan, Zhang Jing, Zhang Xinzhi, Liang Guiping, Xu Tao, Niu Wei. (2019) Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro. Tissue Engineering and Regenerative Medicine, 16 (4): (415-429). [PMID:31413945] [10.1007/s13770-019-00192-0]
38. Guowen Qian, Xingmei Li, Fupo He, Jiandong Ye. (2019) Improving the anti-washout property of calcium phosphate cement by introducing konjac glucomannan/κ-carrageenan blend. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:30661443] [10.1177/0885328218824762]
39. Qian Guowen, Li Xingmei, He Fupo, Ye Jiandong. (2018) Improvement of anti-washout property of calcium phosphate cement by addition of konjac glucomannan and guar gum. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 29 (12): (1-11). [PMID:30511166] [10.1007/s10856-018-6193-7]
40. Shenglei Feng, Fupo He, Jiandong Ye. (2017) Fabrication and characterization of honeycomb β-tricalcium phosphate scaffolds through an extrusion technique. CERAMICS INTERNATIONAL, 43 (6778). [PMID:] [10.1016/j.ceramint.2017.02.094]
41. Ming Wang, Liping Wang, Chao Shi, Tian Sun, Yi Zeng, Yingchun Zhu. (2016) The crystal structure and chemical state of aluminum-doped hydroxyapatite by experimental and first principles calculation studies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18 (31): (21789-21796). [PMID:27436334] [10.1039/C6CP03230C]
42. Peng Wang, Pengzheng Liu, Haitao Peng, Xiaoman Luo, Huipin Yuan, Juncai Zhang, Yonggang Yan. (2016) Biocompatibility evaluation of dicalcium phosphate/calcium sulfate/poly (amino acid) composite for orthopedic tissue engineering in vitro and in vivo. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 27 (11): (1170-1186). [PMID:27126299] [10.1080/09205063.2016.1184123]
43. Xiu Yan Ren, Zhe Yu, Baijun Liu, Xue Jiao Liu, Ya Jun Wang, Qiang Su, Guang Hui Gao. (2016) Highly tough and puncture resistant hydrogels driven by macromolecular microspheres. RSC Advances, 6 (11): (8956-8963). [PMID:] [10.1039/C5RA24778K]

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SKU	Size	Availability	Price	Qty
C108378-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
C108378-500g	500g	In stock	$24.90

Calcium hydrogenphosphate dihydrate - Ph. Eur.,BP,USP,98-102.5%, high purity , CAS No.7789-77-7