Calhex 231 , CAS No.652973-93-8, Allosteric modulator of CaS receptor

Item Number

C275037

Grouped product items
SKU	Size	Availability	Price
C275037-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$128.90
C275037-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$251.90
C275037-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$522.90
C275037-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,999.90
C275037-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,299.90

Negative allosteric modulator of calcium-sensing receptor

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Basic Description

Synonyms	4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]benzamide
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Negative allosteric modulator of calcium-sensing receptor (CaSR). CaSR calcilytic. Blocks (IC 50 = 0.39\xa0μM) increases in\xa0[ 3 H]inositol phosphates due to CaSR activation.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of CaS receptor
Product Description	Shipped at room temperature. Store at -20°C.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-chloro-N-[(1S,2S)-2-[[(1R)-1-naphthalen-1-ylethyl]amino]cyclohexyl]benzamide
INCHI	InChI=1S/C25H27ClN2O/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)27-23-11-4-5-12-24(23)28-25(29)19-13-15-20(26)16-14-19/h2-3,6-10,13-17,23-24,27H,4-5,11-12H2,1H3,(H,28,29)/t17-,23+,24+/m1/s1
InChi Key	YTFUQWWKTIWYEY-CQLNOVPUSA-N
Canonical SMILES	CC(C1=CC=CC2=CC=CC=C21)NC3CCCCC3NC(=O)C4=CC=C(C=C4)Cl
Isomeric SMILES	C[C@H](C1=CC=CC2=CC=CC=C21)N[C@H]3CCCC[C@@H]3NC(=O)C4=CC=C(C=C4)Cl
PubChem CID	11849514
Molecular Weight	406.95

PubChem CID

CAS Registry No.

GPCRdb Ligand

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Basic Description