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Ligand-gated ion channels
P2X receptors
camlipixant , P2X purinoceptor 3 antagonist, CAS No.1621164-74-6, P2X purinoceptor 3 antagonist

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camlipixant , P2X purinoceptor 3 antagonist, CAS No.1621164-74-6, P2X purinoceptor 3 antagonist

Moligand™

CAS#: 1621164-74-6
Formula: C₂₃H₂₄F₂N₄O₄
Molecular Weight: 458.5
PubChem CID: 76955630

Item Number

C608304

Grouped product items
SKU	Size	Availability	Price	Qty
C608304-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$320.90
C608304-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$880.90

View related series

P2X3 Antagonist

Basic Description

Synonyms	Camlipixant\|BLU-5937\|TB7D2H7MZZ\|UNII-TB7D2H7MZZ\|1621164-74-6\|4-Morpholinecarboxylic acid, 2-((2-(2,6-difluoro-4-((methylamino)carbonyl)phenyl)-7-methylimidazo(1,2-a)pyridin-3-yl)methyl)-, methyl ester, (2S)-\|(S)-methyl-2-((2-(2,6-difluoro-4-(methylcarbamo
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	P2X purinoceptor 3 antagonist

Product Properties

ALogP	3.2

Associated Targets

P2RX3 Tclin P2X purinoceptor 3 0 Activities

Discover Target: P2RX3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	methyl (2S)-2-[[2-[2,6-difluoro-4-(methylcarbamoyl)phenyl]-7-methylimidazo[1,2-a]pyridin-3-yl]methyl]morpholine-4-carboxylate
INCHI	InChI=1S/C23H24F2N4O4/c1-13-4-5-29-18(11-15-12-28(6-7-33-15)23(31)32-3)21(27-19(29)8-13)20-16(24)9-14(10-17(20)25)22(30)26-2/h4-5,8-10,15H,6-7,11-12H2,1-3H3,(H,26,30)/t15-/m0/s1
InChi Key	SEHLMRJSQFAPCJ-HNNXBMFYSA-N
Canonical SMILES	CC1=CC2=NC(=C(N2C=C1)C[C@H]3CN(CCO3)C(=O)OC)C4=C(C=C(C=C4F)C(=O)NC)F
Isomeric SMILES	CC1=CC2=NC(=C(N2C=C1)C[C@H]3CN(CCO3)C(=O)OC)C4=C(C=C(C=C4F)C(=O)NC)F
PubChem CID	76955630
Molecular Weight	458.5

Database links

PubChem CID	76955630
ChEMBL Ligand	CHEMBL5095035
CAS Registry No.	1621164-74-6

Certificates

Certificate of Analysis(COA)

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References

1. Garceau D, Chauret N. (2019) BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration.. Pulm Pharmacol Ther, 56 (3): (56-62). [PMID:30902655]

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