Moligand™, from natural, ≥95%(HPLC), from Capsicum sp.
Biochemical and Physiological Mechanisms
Prototypic vanilloid receptor agonist (pEC50values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits agg
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
from natural, Moligand™
Product Description
Capsaicin acts as an agonist at the VR1 (TRPV1) receptor, a ligand-gated non-selective cation channel. It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons. Capsaicin also Inhibits NFκB activation by TNF and reversibly inhibits platelet aggregation. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. A TRPV1 receptor agonist
D2314681
