Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.VR1 vanilloid receptor antagonist (IC 50 = 562 nM). Analgesic in vivo .
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
CHANNEL BLOCKER
Mechanism of action
Channel blocker of TRPM8;Channel blocker of TRPV1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin; potent TRPV1 receptor antagonist with IC50 of 562 nM. An antagonist of TRPV1 and activator of ENaC
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2.Cahusac PM & Noyce R. (2007) A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation.. Neuroscience, 148 (2):(489-500). [PMID:17683869]
3.Adinolfi B et al.. (2013) Anticancer activity of anandamide in human cutaneous melanoma cells.. Eur J Pharmacol, 718 (1-3):(154-9). [PMID:24041928]
4.Landucci E et al.. (2011) CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices.. Neuropharmacology, 60 (4):(674-82). [PMID:21130785]
5.Yan J et al.. (2011) Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache.. Pain, 152 (106-13). [PMID:20971560]
6.de Man JG et al.. (2008) Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors.. Neurogastroenterol Motil, 20 (5):(546-56). [PMID:18194153]
7.De Schepper HU et al.. (2008) TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.. Am J Physiol Gastrointest Liver Physiol, 294 (G245-53). [PMID:17991707]
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C2219280