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G protein-coupled receptors (GPCRs)
Adrenoceptors
Carazolol hydrochloride , CAS No.51997-43-4, Antagonist of β 2-adrenoceptor;Agonist of β 3-adrenoceptor

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Carazolol hydrochloride , CAS No.51997-43-4, Antagonist of β 2-adrenoceptor;Agonist of β 3-adrenoceptor

Moligand™

CAS#: 51997-43-4
Formula: C₁₈H₂₃ClN₂O₂
Molecular Weight: 334.8
PubChem CID: 20032198

Item Number

C276012

Grouped product items
SKU	Size	Availability	Price	Qty
C276012-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$204.90
C276012-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,610.90

High-affinity beta-adrenoceptor ligand.

View related series

β2-adrenoceptor Antagonist β3-adrenoceptor Agonist

Basic Description

Synonyms	Carazolol hydrochloride\|51997-43-4\|Carazolol Hydrochloride Salt\|NSC-305336\|NSC305336\|Carazolol-d6,HydrochlorideSalt\|4IVL5T473E\|1-((9H-Carbazol-4-yl)oxy)-3-(isopropylamino)propan-2-ol hydrochloride\|1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol;hy
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Antagonist of β 2-adrenoceptor;Agonist of β 3-adrenoceptor
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

ADRB2 Tclin Beta-2 adrenergic receptor 1 Activities

Discover Target: ADRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB3 Tclin Beta-3 adrenergic receptor 3 Activities

Discover Target: ADRB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol;hydrochloride
INCHI	InChI=1S/C18H22N2O2.ClH/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16;/h3-9,12-13,19-21H,10-11H2,1-2H3;1H
InChi Key	DXYNUICMBSWZMR-UHFFFAOYSA-N
Canonical SMILES	CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O.Cl
Isomeric SMILES	CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O.Cl
PubChem CID	20032198
Molecular Weight	334.8

Database links

PubChem CID	71739
CAS Registry No.	51997-43-4
Wikipedia	Carazolol
ChEMBL Ligand	CHEMBL324665
BindingDB Ligand	50027663
DrugCentral Ligand	487
GPCRdb Ligand	carazolol

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO

References

1. Innis RB, Corrēa FM, Synder SH. (1979) Carazolol, an extremely potent beta-adrenergic blocker: binding to beta-receptors in brain membranes.. Life Sci, 24 (24): (2255-64). [PMID:41147]

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