Skip to the beginning of the images gallery

Carbacyclin (Carbocyclic PGI₂) - >99%, high purity , CAS No.69552-46-1, Agonist of DP 1 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor

Moligand™
≥99%

CAS#: 69552-46-1
Formula: C₂₁H₃₄O₄
Molecular Weight: 350.49
PubChem CID: 6436393

Item Number

C345266

Grouped product items
SKU	Size	Availability	Price	Qty
C345266-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$395.90

a stable analog of prostacyclin that inhibits platelet aggregation

View related series

DP1 receptor Agonist EP1 receptor Agonist EP2 receptor Agonist EP3 receptor Agonist EP4 receptor Agonist FP receptor Agonist IP receptor Agonist TP receptor Agonist

Basic Description

Synonyms	Carboprostacyclin\|carbacyclin\|Carbaprostacyclin\|69552-46-1\|(5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid\|Carba pgx\|6a-Carba-pgi2\|6,9-Methano pgi2\|6,9-Methano-pgi2\|(5E)-5-[(3aS
Specifications & Purity	Moligand™, ≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of DP 1 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor
Product Description	Carbacyclin is a stable prostacyclin analog found to inhibit platelet aggregation induced by collagen or ADP. In experiments shown to reduce systemic arterial blood pressure in various animals. Displays ability to relax bovine coronary arteries and human respiratory smooth muscles. Also evident to act as an effector for preadipose cell differentiation. Very useful mimic of prostacyclin with lower potency. Suggested to be an IP Receptor and PPARβ activator.

Associated Targets

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype 2 Activities

Discover Target: PTGER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 1 Activities

Discover Target: PTGDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 2 Activities

Discover Target: PTGER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype 1 Activities

Discover Target: PTGER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGFR Tclin Prostaglandin F2-alpha receptor 1 Activities

Discover Target: PTGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor 1 Activities

Discover Target: PTGIR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype 2 Activities

Discover Target: PTGER3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 1 Activities

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
INCHI	InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7+/t16-,17-,18+,19-,20+/m0/s1
InChi Key	XZFRIPGNUQRGPI-WBQKLGIQSA-N
Canonical SMILES	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Isomeric SMILES	CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)O
WGK Germany	3
PubChem CID	6436393
Molecular Weight	350.49

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

GPCRdb Ligand

Solubility

Soluble in ethanol (25 mg/ml), DMSO, acetone, ethyl acetate, PBS (pH7.2) (~0.8 mg/ml), and DMF (~5 mg/ml).

Refractive Index

n20D1.61

Boil Point(°C)

514.79° C at 760 mmHg

Melt Point(°C)

65-67° C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.