Carboplatin - 98%, high purity , CAS No.41575-94-4

2 Citations
Item Number
C110682
Grouped product items
SKUSizeAvailabilityPrice Qty
C110682-100mg
100mg
In stock
$75.90
C110682-250mg
250mg
In stock
$129.90
C110682-1g
1g
In stock
$359.90
C110682-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$999.90

Antitumor agent; blocks DNA replication and transcription. Cisplatin analog.

Basic Description

Synonymscis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) | 1,1-Cyclobutanedicarboxylatodiammineplatinum(II)
Specifications & Purity98%
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Product Description
Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
An antitumor agent that binds to DNA leading to apoptosis

Product Application
Carboplatin has been used: in chemotherapy-induced thrombocytopenia mouse model and treatment to induce cell death in a large subset of colorectal cancer cells in the evaluation of cell proliferation and chemosensitivity 

as a positive control for suppressed cell growth

Product class
hAPIs, Metal based hAPIs

Chemical properties

Chemical formula

C6H12N2O4Pt

Empirical formula

[Pt(NH3)2(cbdc)]

Molecular weight

371.25

Metal

Pt

Theoretical metal content

53

Physical state

powder

Color

white

Names and Identifiers

IUPAC Name azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
INCHI InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
InChi Key VSRXQHXAPYXROS-UHFFFAOYSA-N
Canonical SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Isomeric SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
WGK Germany 3
RTECS TP2300000
Alternate CAS 41575-94-4
PubChem CID 426756
NSC Number 201345
MeSH Entry Terms Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo
Molecular Weight 371.25
Reaxy-Rn 13598388

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
H2419358Certificate of AnalysisAug 08, 2024 C110682
H2419273Certificate of AnalysisAug 08, 2024 C110682
H2419352Certificate of AnalysisAug 08, 2024 C110682
H2419353Certificate of AnalysisAug 08, 2024 C110682
D2411199Certificate of AnalysisMar 29, 2024 C110682
D2411200Certificate of AnalysisMar 29, 2024 C110682
D2420052Certificate of AnalysisMar 26, 2024 C110682
D2420053Certificate of AnalysisMar 26, 2024 C110682
K2222258Certificate of AnalysisOct 28, 2022 C110682
K2222257Certificate of AnalysisOct 28, 2022 C110682
K2222253Certificate of AnalysisOct 28, 2022 C110682
K2222249Certificate of AnalysisOct 28, 2022 C110682
C2421016Certificate of AnalysisOct 28, 2022 C110682
B2225785Certificate of AnalysisSep 26, 2021 C110682
B2225784Certificate of AnalysisSep 26, 2021 C110682
B2225769Certificate of AnalysisSep 26, 2021 C110682
B2225753Certificate of AnalysisSep 26, 2021 C110682

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Chemical and Physical Properties

SolubilitySoluble in water.DMSO can inactivate Carboplatin's activity.
SensitivityLight sensitive.
Melt Point(°C)>275℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H312:Harmful in contact with skin

H332:Harmful if inhaled

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H340:May cause genetic defects

H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled

H362:May cause harm to breast-fed children

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3
RTECS TP2300000
Reaxy-Rn 13598388
Merck Index 1822

Related Documents

FAQs and Articles

Citations of This Product

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong.  (2023)  Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  21  (1): (1-19).  [PMID:37120558]
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255]

References

1. Gonzalez Rajal A et al..  (2021)  A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma..  Elife,  10    [PMID:33983115]
2. Hastings JF et al..  (2020)  Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma..  Elife,    [PMID:32513387]
3. Ke FY et al..  (2020)  Novel monoclonal antibody against integrin a3 shows therapeutic potential for ovarian cancer..  Cancer Sci,  111  (10): (3478-3492).  [PMID:32648337]
4. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong.  (2023)  Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  21  (1): (1-19).  [PMID:37120558]
5. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255]

Solution Calculators