| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C295384-100mg | 100mg | In stock | $58.90 |
Antitumor agent; blocks DNA replication and transcription. Cisplatin analog.
| Synonyms | AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatinum | DTXCID201476080 | Amikacin impurity I, European Pharmacopoeia (EP) Reference Standard | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201345 | |
|---|---|
| Specifications & Purity | Moligand™, ≥99.95% metals basis |
| Legal Information | Product of Umicore |
| Storage Temp | Store at 2-8°C,Protected from light |
| Shipped In | Wet ice |
| Grade | Moligand™ |
| Product Description | Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action. Product class Chemical properties Chemical formula C6H12N2O4Pt Empirical formula [Pt(NH3)2(cbdc)] Molecular weight 371.25 Metal Pt Theoretical metal content 53 Physical state powder Color Metal purity white 99.95 |
| IUPAC Name | azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) |
|---|---|
| INCHI | InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2 |
| InChi Key | VSRXQHXAPYXROS-UHFFFAOYSA-N |
| Canonical SMILES | C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2] |
| Isomeric SMILES | C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2] |
| WGK Germany | 3 |
| RTECS | TP2300000 |
| Alternate CAS | 41575-94-4 |
| PubChem CID | 426756 |
| NSC Number | 201345 |
| MeSH Entry Terms | Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo |
| Molecular Weight | 371.25 |
| Reaxy-Rn | 13598388 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2325031 | Certificate of Analysis | Jun 27, 2023 | C295384 |
| Solubility | Soluble in water. |
|---|---|
| Sensitivity | Light sensitive. |
| Melt Point(°C) | >275℃ |
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H362:May cause harm to breast-fed children |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
| WGK Germany | 3 |
| RTECS | TP2300000 |
| Reaxy-Rn | 13598388 |
| Merck Index | 1822 |
| 1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558] [10.1186/s12951-023-01901-7] |
| 2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002] |
| 3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang. (2021) Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin. Translational Cancer Research, 10 (3): ( 1183–1192). [PMID:35116446] [10.21037/tcr-20-3035] |
| 4. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] [10.3892/or.2020.7647] |
| 5. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184] |
| 1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558] [10.1186/s12951-023-01901-7] |
| 2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002] |
| 3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang. (2021) Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin. Translational Cancer Research, 10 (3): ( 1183–1192). [PMID:35116446] [10.21037/tcr-20-3035] |
| 4. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] [10.3892/or.2020.7647] |
| 5. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184] |
