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C423884-1ml

1ml

Available within 4-8 weeks(?)

$467.90

Basic Description

Synonyms	41575-94-4 \| Carboplatin \| Paraplatin \| Cbdca \| Carboplatinum \| MFCD00070464 \| NSC-241240 \| cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) \| cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) \| 1,1-Cyclobutanedicarboxylate diammine platinum(II) \| cis-Diammine(1,1
Specifications & Purity	Moligand™, 10mM in Water
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Product Description Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action. An antitumor agent that binds to DNA leading to apoptosis Product Application Carboplatin has been used: in chemotherapy-induced thrombocytopenia mouse model and treatment to induce cell death in a large subset of colorectal cancer cells in the evaluation of cell proliferation and chemosensitivity as a positive control for suppressed cell growth Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula C6H12N2O4Pt Empirical formula [Pt(NH3)2(cbdc)] Molecular weight 371.25 Metal Pt Theoretical metal content 53 Physical state powder Color white

Names and Identifiers

IUPAC Name	azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
INCHI	InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);21H2;/q;2-1;+2
InChi Key	VSRXQHXAPYXROS-UHFFFAOYSA-N
Canonical SMILES	C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Isomeric SMILES	C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
WGK Germany	3
RTECS	TP2300000
Alternate CAS	41575-94-4
PubChem CID	426756
NSC Number	201345
MeSH Entry Terms	Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo
Molecular Weight	371.25
Reaxy-Rn	13598388

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Light sensitive.
Melt Point(°C)	>275℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	TP2300000
Reaxy-Rn	13598388
Merck Index	1822

FAQs and Articles

FAQ

DNA Damage and Repair

Categories: Technical articles

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inhibitor DNA

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558] [10.1186/s12951-023-01901-7]
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang. (2021) Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin. Translational Cancer Research, 10 (3): ( 1183–1192). [PMID:35116446] [10.21037/tcr-20-3035]
4. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] [10.3892/or.2020.7647]
5. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184]

References

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558] [10.1186/s12951-023-01901-7]
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang. (2021) Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin. Translational Cancer Research, 10 (3): ( 1183–1192). [PMID:35116446] [10.21037/tcr-20-3035]
4. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] [10.3892/or.2020.7647]
5. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184]

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Carboplatin - 10mM in Water, high purity , CAS No.41575-94-4