Grouped product items

SKU

Size

Availability

Price

Qty

C423884-1ml

1ml

Available within 4-8 weeks(?)

$467.90

Basic Description

Synonyms	41575-94-4 \| Carboplatin \| Paraplatin \| Cbdca \| Carboplatinum \| MFCD00070464 \| NSC-241240 \| cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) \| cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) \| 1,1-Cyclobutanedicarboxylate diammine platinum(II) \| cis-Diammine(1,1
Specifications & Purity	10mM in Water
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Product Description Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action. An antitumor agent that binds to DNA leading to apoptosis Product Application Carboplatin has been used: in chemotherapy-induced thrombocytopenia mouse model and treatment to induce cell death in a large subset of colorectal cancer cells in the evaluation of cell proliferation and chemosensitivity as a positive control for suppressed cell growth Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula C6H12N2O4Pt Empirical formula [Pt(NH3)2(cbdc)] Molecular weight 371.25 Metal Pt Theoretical metal content 53 Physical state powder Color white

Names and Identifiers

IUPAC Name	azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
INCHI	InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);21H2;/q;2-1;+2
InChi Key	VSRXQHXAPYXROS-UHFFFAOYSA-N
Canonical SMILES	C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Isomeric SMILES	C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
WGK Germany	3
RTECS	TP2300000
Alternate CAS	41575-94-4
PubChem CID	426756
NSC Number	201345
MeSH Entry Terms	Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo
Molecular Weight	371.25
Reaxy-Rn	13598388

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Sensitivity	Light sensitive.
Melt Point(°C)	>275℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	TP2300000
Reaxy-Rn	13598388
Merck Index	1822

FAQs and Articles

FAQ

DNA Damage and Repair

Categories: Technical articles

Tags:

inhibitor DNA

Citations of This Product

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558]
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255]

References

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong. (2023) Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-19). [PMID:37120558]
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Carboplatin - 10mM in Water, high purity , CAS No.41575-94-4