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carotegrast , CAS No.401904-75-4, Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)

Moligand™
≥98%

CAS#: 401904-75-4
Formula: C₂₇H₂₄Cl₂N₄O₅
Molecular Weight: 555.41
PubChem CID: 10120218

Item Number

C608326

Grouped product items
SKU	Size	Availability	Price
C608326-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
C608326-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608326-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
C608326-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90
C608326-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90
C608326-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,529.90

View related series

integrin α4β1 Inhibitor integrin α4β7 Inhibitor integrin，alpha 4 subunit (antigen CD49D，alpha 4 subunit of VLA-4 receptor) Inhibitor

Basic Description

Synonyms	Carotegrast\|401904-75-4\|Carotegrast [INN]\|UNII-Y1HYC6SO3F\|Y1HYC6SO3F\|(2S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2h)-yl)phenyl)propanoic acid\|CHEMBL4592659\|(2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[6-(
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Product Description	Carotegrast is an α4 integrin receptor inhibitor with anti-inflammatories activities.发送消息记录备注安排活动 2 正在关注中 0

Associated Targets

ITGA4 Tclin Integrin alpha-4 0 Activities

Discover Target: ITGA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB7 Tclin Integrin beta-7 0 Activities

Discover Target: ITGB7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB1 Tclin Integrin beta-1 0 Activities

Discover Target: ITGB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[6-(dimethylamino)-1-methyl-2,4-dioxoquinazolin-3-yl]phenyl]propanoic acid
INCHI	InChI=1S/C27H24Cl2N4O5/c1-31(2)17-11-12-22-18(14-17)25(35)33(27(38)32(22)3)16-9-7-15(8-10-16)13-21(26(36)37)30-24(34)23-19(28)5-4-6-20(23)29/h4-12,14,21H,13H2,1-3H3,(H,30,34)(H,36,37)/t21-/m0/s1
InChi Key	YQKBOUPIOWUMTE-NRFANRHFSA-N
Canonical SMILES	CN1C2=C(C=C(C=C2)N(C)C)C(=O)N(C1=O)C3=CC=C(C=C3)CC(C(=O)O)NC(=O)C4=C(C=CC=C4Cl)Cl
Isomeric SMILES	CN1C2=C(C=C(C=C2)N(C)C)C(=O)N(C1=O)C3=CC=C(C=C3)C[C@@H](C(=O)O)NC(=O)C4=C(C=CC=C4Cl)Cl
Alternate CAS	401904-75-4
PubChem CID	10120218
Molecular Weight	555.41

PubChem CID

10120218

CAS Registry No.

401904-75-4

References

1. Sugiura T, Kageyama S, Andou A, Miyazawa T, Ejima C, Nakayama A, Dohi T, Eda H. (2013) Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice.. J Crohns Colitis, 7 (11): (e533-42). [PMID:23623333]
2. Vetter M, Neurath MF. (2017) Emerging oral targeted therapies in inflammatory bowel diseases: opportunities and challenges.. Therap Adv Gastroenterol, 10 (10): (773-790). [PMID:29051788]
3. White JR, Phillips F, Monaghan T, Fateen W, Samuel S, Ghosh S, Moran GW. (2018) Review article: novel oral-targeted therapies in inflammatory bowel disease.. Aliment Pharmacol Ther, 47 (12): (1610-1622). [PMID:29672874]
4. Fukase H, Kajioka T, Oikawa I, Ikeda N, Furuie H. (2020) AJM300, a novel oral antagonist of α4-integrin, sustains an increase in circulating lymphocytes: A randomised controlled trial in healthy male subjects.. Br J Clin Pharmacol, 86 (3): (591-600). [PMID:31658381]
5. Shukla T, Sands BE. (2019) Novel Non-biologic Targets for Inflammatory Bowel Disease.. Curr Gastroenterol Rep, 21 (5): (22). [PMID:31016396]

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carotegrast , CAS No.401904-75-4, Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)

Basic Description

Associated Targets

ITGA4 Tclin Integrin alpha-4 0 Activities

ITGB7 Tclin Integrin beta-7 0 Activities

ITGB1 Tclin Integrin beta-1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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